Evidence map›Paper›PMID 27738828›Full record

ArticleLung2016

Intermittent Hypoxia Contributes to the Lung Damage by Increased Oxidative Stress, Inflammation, and Disbalance in Protease/Antiprotease System.

I Tuleta, F Stöckigt, U R Juergens, C Pizarro, J W Schrickel, G Kristiansen, G Nickenig, D Skowasch

Abstract read
PubMed Publisher
In one paragraph

Article in Lung, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 52 citations in OpenAlex.

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  15. Bidirectional relationships of comorbidity with obstructive sleep apnoea.European respiratory review : an official journal of the European Respiratory Society · 2022
    Review
  16. OSA and Chronic Respiratory Disease: Mechanisms and Epidemiology.International journal of environmental research and public health · 2022
    Review
  17. Article
  18. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

I TuletaDepartment of Internal Medicine II - Cardiology, Pneumology and Angiology, University of Bonn, Sigmund-Freud-Str. 25, 53105, Bonn, Germany. Izabela.Tuleta@ukb.uni-bonn.de.
F StöckigtDepartment of Internal Medicine II - Cardiology, Pneumology and Angiology, University of Bonn, Sigmund-Freud-Str. 25, 53105, Bonn, Germany.
U R JuergensDepartment of Internal Medicine II - Cardiology, Pneumology and Angiology, University of Bonn, Sigmund-Freud-Str. 25, 53105, Bonn, Germany.
C PizarroDepartment of Internal Medicine II - Cardiology, Pneumology and Angiology, University of Bonn, Sigmund-Freud-Str. 25, 53105, Bonn, Germany.
J W SchrickelDepartment of Internal Medicine II - Cardiology, Pneumology and Angiology, University of Bonn, Sigmund-Freud-Str. 25, 53105, Bonn, Germany.
G KristiansenInstitute of Pathology, University of Bonn, Bonn, Germany.
G NickenigDepartment of Internal Medicine II - Cardiology, Pneumology and Angiology, University of Bonn, Sigmund-Freud-Str. 25, 53105, Bonn, Germany.
D SkowaschDepartment of Internal Medicine II - Cardiology, Pneumology and Angiology, University of Bonn, Sigmund-Freud-Str. 25, 53105, Bonn, Germany.
University of Bonn · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionIntermittent hypoxia as a surrogate of obstructive sleep apnea is associated with different cardiovascular complications. However, the effects of intermittent hypoxia on the lung tissue are less known. Therefore, the aim of our present study was to investigate if intermittent hypoxia may influence oxidative stress, inflammation, and protease/antiprotease system in the lung. Additionally, potential protective properties of anti-inflammatory and anti-oxidative drugs have been evaluated.

methods32 mice were divided into four groups: (1) intermittent hypoxia, (2) intermittent hypoxia with infliximab, (3) intermittent hypoxia with L-glutathione, and (4) normoxia. After 4 weeks, lungs and blood were collected. Levels of reactive oxygen species in the lung were calculated by L-O12-enhanced chemiluminescence. CD68-positive lung macrophages were detected by immunofluorescence. Concentrations of elastase and desmosine in lung and of alpha-1-antitrypsin in blood were calculated by means of enzyme-linked immunosorbent assay.

resultsCompared to a control, intermittent hypoxia augmented the release of free oxygen radicals, expression of CD68+ macrophages, and concentration of elastase in the lung tissue. Despite increased blood levels of protective alpha-1-antitrypsin, concentrations of desmosine-degradation product of elastin were higher versus control. The application of anti-inflammatory infliximab und anti-oxidative L-glutathione prevented at least partly the above-observed hypoxia-associated changes.

conclusionsIntermittent hypoxia contributes to the lung damage by increased oxidative stress, inflammation, and disbalance in protease/antiprotease system. Infliximab and L-glutathione may prevent adverse hypoxia-induced lung alternations.

Indexed as

Oxidative Stressalpha 1-AntitrypsinAnimalsAntigens, CDAntigens, Differentiation, MyelomonocyticAnti-Inflammatory AgentsAntioxidantsCD68 MoleculeDesmosineFemaleGlutathioneHypoxiaInflammationInfliximabLungMacrophagesalpha 1-AntitrypsinAntigens, CDAntigens, Differentiation, MyelomonocyticAnti-Inflammatory AgentsAntioxidantsCD68 MoleculeCD68 protein, mouseDesmosineGlutathioneInfliximabPancreatic ElastaseReactive Oxygen SpeciesAntiproteasesInflammationIntermittent hypoxiaOxidative stressProteases

Identifiers

PMID27738828
OpenAlexW2530765339

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.