Trial reportEuropean journal of nuclear medicine and molecular imaging2017
Short-term changes in arterial inflammation predict long-term changes in atherosclerosis progression.
Trial report in European journal of nuclear medicine and molecular imaging, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 25 citations in OpenAlex.
- Modulation of Cardiometabolic Disease Markers by Type I Interferon Inhibition in Systemic Lupus Erythematosus.Arthritis & rheumatology (Hoboken, N.J.) · 2021Trial
- PET Imaging of Carotid Atherosclerosis: Methodology, Implications, and Applications in Neurovascular Disease.Stroke · 2026Review
- Unusual Evolution of Carotid Atherosclerosis in a Patient with Transient Ischemic Attack.Life (Basel, Switzerland) · 2025Article
- Local and systemic factors associated with quantitative stiffness of carotid plaque.Acta neurochirurgica · 2024Article
- A role for artificial intelligence in molecular imaging of infection and inflammation.European journal of hybrid imaging · 2022Review
- Scan-rescan measurement repeatability ofJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022Article
- Article
- Clinical imaging of cardiovascular inflammation.The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of... · 2020Review
- Molecular Imaging of Atheroma: Deciphering How and When to UseCirculation. Cardiovascular imaging · 2017Article
- Molecular Imaging of Atherosclerosis: A Clinical Focus.Current cardiovascular imaging reports · 2017Article
- Monitoring inflammation injuries in the progression of atherosclerosis with contrast enhanced ultrasound molecular imaging.PloS one · 2017Article
- Imaging High-Risk Atherosclerotic Plaques with PET.Current treatment options in cardiovascular medicine · 2016Review
- Role ofWorld journal of nuclear medicineReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeIt remains unclear whether changes in arterial wall inflammation are associated with subsequent changes in the rate of structural progression of atherosclerosis.
methodsIn this sub-study of the dal-PLAQUE clinical trial, multi-modal imaging was performed using 18-fludeoxyglucose (FDG) positron emission tomography (PET, at 0 and 6 months) and magnetic resonance imaging (MRI, at 0 and 24 months). The primary objective was to determine whether increasing FDG uptake at 6 months predicted atherosclerosis progression on MRI at 2 years. Arterial inflammation was measured by the carotid FDG target-to-background ratio (TBR), and atherosclerotic plaque progression was defined as the percentage change in carotid mean wall area (MWA) and mean wall thickness (MWT) on MRI between baseline and 24 months.
resultsA total of 42 participants were included in this sub-study. The mean age of the population was 62.5 years, and 12 (28.6 %) were women. In participants with (vs. without) any increase in arterial inflammation over 6 months, the long-term changes in both MWT (% change MWT: 17.49 % vs. 1.74 %, p = 0.038) and MWA (% change MWA: 25.50 % vs. 3.59 %, p = 0.027) were significantly greater. Results remained significant after adjusting for clinical and biochemical covariates. Individuals with no increase in arterial inflammation over 6 months had no significant structural progression of atherosclerosis over 24 months as measured by MWT (p = 0.616) or MWA (p = 0.373).
conclusionsShort-term changes in arterial inflammation are associated with long-term structural atherosclerosis progression. These data support the concept that therapies that reduce arterial inflammation may attenuate or halt progression of atherosclerosis.
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