Evidence map›Paper›PMID 27738697›Full record

ArticleNanoscale2016

Cytosolic delivery of large proteins using nanoparticle-stabilized nanocapsules.

Rui Tang, Ziwen Jiang, Moumita Ray, Singyuk Hou, Vincent M Rotello

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nanoscale, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Intracellular delivery of proteins for live cell imaging.Journal of controlled release : official journal of the Controlled Release Society · 2025
    Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Review
  7. Review
  8. Active Targeting of the Nucleus Using Nonpeptidic Boronate Tags.Journal of the American Chemical Society · 2017
    Article
  9. Article
  10. Intracellular delivery of proteins by nanocarriers.Nanomedicine (London, England) · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Rui TangDepartment of Chemistry, University of Massachusetts Amherst, 710 North Pleasant Street, Amherst, Massachusetts 01003, USA. rotello@chem.umass.edu.ORCID http://orcid.org/0000-0002-3161-801X
Ziwen JiangDepartment of Chemistry, University of Massachusetts Amherst, 710 North Pleasant Street, Amherst, Massachusetts 01003, USA. rotello@chem.umass.edu.ORCID http://orcid.org/0000-0002-6633-7824
Moumita RayDepartment of Chemistry, University of Massachusetts Amherst, 710 North Pleasant Street, Amherst, Massachusetts 01003, USA. rotello@chem.umass.edu.
Singyuk HouDepartment of Chemistry, University of Massachusetts Amherst, 710 North Pleasant Street, Amherst, Massachusetts 01003, USA. rotello@chem.umass.edu.
Vincent M RotelloDepartment of Chemistry, University of Massachusetts Amherst, 710 North Pleasant Street, Amherst, Massachusetts 01003, USA. rotello@chem.umass.edu.

Funding

Recognition and Presentation of Alpha Helices using Nanoparticle ReceptorsR01GM077173 · NIGMS · UNIVERSITY OF MASSACHUSETTS AMHERST · PI ROTELLO, VINCENT M. · 2007 to 2018
$3.7M
NIGMS NIH HHS R01 GM077173
6 · The paper itself

Abstract

We report an effective intracellular delivery strategy for proteins of high molecular weight using AuNP stabilized capsules. This strategy provides direct delivery to the cytosol, avoiding endosomal entrapment.

Indexed as

Drug Delivery SystemsMetal NanoparticlesNanocapsulesCytosolEndosomesGoldHeLa CellsHumansProteinsGoldNanocapsulesProteins

Identifiers

PMID27738697
PMCPMC5137506

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.