Evidence map›Paper›PMID 27738656›Full record

ArticleTomography (Ann Arbor, Mich.)2016

Combination of an Integrin-Targeting NIR Tracer and an Ultrasensitive Spectroscopic Device for Intraoperative Detection of Head and Neck Tumor Margins and Metastatic Lymph Nodes.

Younghyoun Yoon, Aaron M Mohs, Michael C Mancini, Shuming Nie, Hyunsuk Shim

Open access · goldAbstract read
In one paragraph

Article in Tomography (Ann Arbor, Mich.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Younghyoun YoonDepartment of Radiology and Imaging Science, Emory University School of Medicine, Atlanta, Georgia.
Aaron M MohsDepartment of Biomedical Engineering, Emory University and Georgia Institute of Technology, Atlanta, Georgia; Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, Nebraska.
Michael C ManciniDepartment of Biomedical Engineering, Emory University and Georgia Institute of Technology, Atlanta, Georgia.
Shuming NieDepartment of Biomedical Engineering, Emory University and Georgia Institute of Technology, Atlanta, Georgia.
Hyunsuk ShimDepartment of Radiology and Imaging Science, Emory University School of Medicine, Atlanta, Georgia; Department of Biomedical Engineering, Emory University and Georgia Institute of Technology, Atlanta, Georgia; Winship Cancer Institute, Emory University, Atlanta, Georgia.
Georgia Institute of Technology · USEmory University · US

Funding

Contrast-Enhanced and Image-Guided Surgery of Lung CancerR01CA163256 · NCI · EMORY UNIVERSITY · PI JO, HANJOONG, SINGHAL, SUNIL · 2011 to 2015
$6.5M
Development of anti-CXCR4 compounds to block breast cancer metastasisR01CA165306 · NCI · EMORY UNIVERSITY · PI SHIM, HYUNSUK · 2012 to 2016
$1.7M
Development of anti-CXCR4 compounds as anti-metastatic, angiogenic drugR01CA109366 · NCI · EMORY UNIVERSITY · PI SHIM, HYUNSUK · 2006 to 2010
$1.3M
Nanotechnology for Minimally Invasive Cancer Detection and ResectionR00CA153916 · NCI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI MOHS, AARON M. · 2012 to 2014
$708k
Nanotechnology for Minimally Invasive Cancer Detection and ResectionK99CA153916 · NCI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI MOHS, AARON M. · 2010 to 2011
$186k
NCI NIH HHS K99 CA153916NCI NIH HHS R00 CA153916NCI NIH HHS R01 CA109366NCI NIH HHS R01 CA163256NCI NIH HHS R01 CA165306
6 · The paper itself

Abstract

Despite major advances in targeted drug therapy and radiation therapy, surgery remains the most effective treatment for most solid tumors. The single most important predictor of patient survival is a complete surgical resection of the primary tumor, draining lymph nodes, and metastatic lesions. Presently, however, 20%-30% of patients with head and neck cancer who undergo surgery still leave the operating room without complete resection because of missed lesions. Thus, major opportunities exist to develop advanced imaging tracers and intraoperative instrumentation that would allow surgeons to visualize microscopic tumors during surgery. The cell adhesion molecule integrin

Indexed as

head and neck cancerinfiltrativeintraoperative guidancelymph nodesmetastaticnear-infraredRGDtumor margins

Identifiers

PMID27738656
PMCPMC5058361
OpenAlexW2556643465

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.