Evidence map›Paper›PMID 27738630›Full record

ArticleBioMed research international2016

The -174G/C Interleukin-6 Gene Promoter Polymorphism as a Genetic Marker of Differences in Therapeutic Response to Methotrexate and Leflunomide in Rheumatoid Arthritis.

A J Ruiz-Padilla, J I Gamez-Nava, A M Saldaña-Cruz, J D Murillo-Vazquez, M L Vazquez-Villegas, S A Zavaleta-Muñiz, B T Martín-Márquez, J M Ponce-Guarneros, N A Rodriguez Jimenez, A Flores-Chavez and 5 more

Open access · hybridAbstract read
In one paragraph

Article in BioMed research international, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.2field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 1 country.

A J Ruiz-PadillaDepartamento de Medicina Interna-Reumatología, Hospital General Regional 110, IMSS, 44710 Guadalajara, JAL, Mexico; Doctorado en Farmacología, Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara (U de G), 44340 Guadalajara, JAL, Mexico.
J I Gamez-NavaCentro Universitario de Ciencias de la Salud, Universidad de Guadalajara, 44340 Guadalajara, JAL, Mexico; Unidad de Investigación en Epidemiología Clínica, Centro Médico Nacional de Occidente (CMNO), Instituto Mexicano del Seguro Social (IMSS), Hospital de Especialidades, 44340 Guadalajara, JAL, Mexico.ORCID 0000-0003-0001-3787
A M Saldaña-CruzCentro Universitario de Investigaciones Biomédicas (CUIB), Universidad de Colima, 28040 Colima, COL, Mexico.
J D Murillo-VazquezDoctorado en Farmacología, Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara (U de G), 44340 Guadalajara, JAL, Mexico; Unidad de Investigación en Epidemiología Clínica, Centro Médico Nacional de Occidente (CMNO), Instituto Mexicano del Seguro Social (IMSS), Hospital de Especialidades, 44340 Guadalajara, JAL, Mexico.
M L Vazquez-VillegasDepartamento de Epidemiología, Unidad Médica Familiar 4, IMSS, 44220 Guadalajara, JAL, Mexico; Departamento de Salud Pública, CUCS, U de G, 44340 Guadalajara, JAL, Mexico.
S A Zavaleta-MuñizDivisión de Posgrado, Facultad de Ciencias de la Salud, Universidad Juárez del Estado de Durango, 35050 Gómez Palacio, DGO, Mexico.ORCID 0000-0001-6572-3507
B T Martín-MárquezInstituto de Investigación en Reumatología y del Sistema Músculo Esquelético (IIRSME), CUCS, U de G, 44340 Guadalajara, JAL, Mexico.ORCID 0000-0002-6756-4316
J M Ponce-GuarnerosDoctorado en Farmacología, Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara (U de G), 44340 Guadalajara, JAL, Mexico; Unidad Médica Familiar 97, IMSS, 46470 Magdalena, JAL, Mexico.
N A Rodriguez JimenezDepartamento de Medicina Interna-Reumatología, Hospital General Regional 110, IMSS, 44710 Guadalajara, JAL, Mexico; Doctorado en Farmacología, Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara (U de G), 44340 Guadalajara, JAL, Mexico.ORCID 0000-0001-7643-6298
A Flores-ChavezUnidad de Investigación en Epidemiología Clínica, Centro Médico Nacional de Occidente (CMNO), Instituto Mexicano del Seguro Social (IMSS), Hospital de Especialidades, 44340 Guadalajara, JAL, Mexico; Centro Universitario de Investigaciones Biomédicas (CUIB), Universidad de Colima, 28040 Colima, COL, Mexico.
F Sandoval-GarciaInstituto de Investigación en Reumatología y del Sistema Músculo Esquelético (IIRSME), CUCS, U de G, 44340 Guadalajara, JAL, Mexico.
J C Vasquez-JimenezCentro Universitario de Investigaciones Biomédicas (CUIB), Universidad de Colima, 28040 Colima, COL, Mexico.
E G Cardona-MuñozDepartamento de Fisiología, CUCS, U de G, 44340 Guadalajara, JAL, Mexico.ORCID 0000-0001-7868-667X
S E Totsuka-SuttoDepartamento de Fisiología, CUCS, U de G, 44340 Guadalajara, JAL, Mexico.
L Gonzalez-LopezDepartamento de Medicina Interna-Reumatología, Hospital General Regional 110, IMSS, 44710 Guadalajara, JAL, Mexico; Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, 44340 Guadalajara, JAL, Mexico.ORCID 0000-0002-6517-6344
Mexican Social Security Institute · MXUniversidad de Guadalajara · MXUniversidad de Colima · MXUniversidad Juárez del Estado de Durango · MX

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AgedArthritis, RheumatoidBiomarkers, PharmacologicalFemaleGenetic MarkersGenotypeHumansInterleukin-6IsoxazolesLeflunomideMaleMethotrexateMiddle AgedPolymorphism, Single NucleotidePromoter Regions, GeneticBiomarkers, PharmacologicalGenetic MarkersInterleukin-6IsoxazolesLeflunomideMethotrexate

Identifiers

PMID27738630
PMCPMC5050320
OpenAlexW2522096905

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.