ArticleBMJ open diabetes research & care2016
Association between liver enzymes and incident type 2 diabetes in Singapore Chinese men and women.
Article in BMJ open diabetes research & care, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 73 citations in OpenAlex.
- Interaction Patterns Among Risk Factors for Liver Cancer in Patients With Type 2 Diabetes in Primary Care: A Retrospective Cohort Study.Health science reports · 2026Article
- Machine learning-based binary classification of elevated HbA1c (≥6.5 %) for risk assessment.Metabolism open · 2026Article
- Effects of hawthorn vinegar on high-fat diet-induced metabolic changes in obese rat model.Hormones (Athens, Greece) · 2026Article
- Machine-learning-based prediction model of type 2 diabetes using liver enzymes: a cross-sectional study.Frontiers in endocrinology · 2026Article
- Comparison Between the Impact of Diabetes Mellitus on Liver Diseases and Vice Versa Among Saudi and Egyptian Patients.Healthcare (Basel, Switzerland) · 2025Article
- Elevated liver enzymes and diabetes in the PERSIAN Guilan cohort study.Caspian journal of internal medicine · 2025Article
- Metabolic dysfunction associated fatty liver disease and type 2 diabetes: pathophysiological links, epidemiological trends, and clinical implications.Frontiers in endocrinology · 2025Review
- Serum Gamma Glutamyl Transferase: Understanding its Contribution as a Potential Predictor of the Occurrence of Type 2 Diabetes.Current diabetes reviews · 2024Review
- Association of lactate dehydrogenase and diabetic retinopathy in US adults with diabetes mellitus.Journal of diabetes · 2024Article
- The relationship between the ratio of gamma-glutamyltransferase to high-density lipoprotein cholesterol and the risk of diabetes mellitus using publicly available data: a secondary analysis based on a longitudinal study in Japan.Lipids in health and disease · 2023Article
- Diabetes and diabesity in the view of proteomics, drug, and plant-derived remedies.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2023Review
- Association Between Serum Aminotransferases and Risk of New-Onset Cardiometabolic Disease in a Healthy Chinese Population: A Cohort Study.Frontiers in public health · 2022Article
- Assessment of the relationship of serum liver enzymes activity with general and abdominal obesity in an urban Bangladeshi population.Scientific reports · 2021Article
- Epidemiology of Isolated Impaired Glucose Tolerance Among Adults Aged Above 50 Years in Rural China.Diabetes, metabolic syndrome and obesity : targets and therapy · 2021Article
- Tissue inhibitor matrix metalloproteinase 1 and risk of type 2 diabetes in a Chinese population.BMJ open diabetes research & care · 2020Article
- Prevalence of elevated liver enzymes and its association with type 2 diabetes: A cross-sectional study in Bangladeshi adults.Endocrinology, diabetes & metabolism · 2020Article
- Shorter leucocyte telomere length as a potential biomarker for nonalcoholic fatty liver disease-related advanced fibrosis in T2DM patients.Annals of translational medicine · 2020Article
- Assessment of liver marker enzymes and its association with type 2 diabetes mellitus in Northwest Ethiopia.BMC research notes · 2019Article
- Mapping the evidence of hepatoprotective properties of Moringa oleifera from sub-Saharan African countries: a systematic review protocol.Systematic reviews · 2019Article
- Plasma Fetuin-A Levels and Risk of Type 2 Diabetes Mellitus in A Chinese Population: A Nested Case-Control Study.Diabetes & metabolism journal · 2019Article
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Authors and funding
4 authors at 3 institutions in 3 countries.
Funding
Abstract
aimsTo assess the association between liver enzymes and the risk of type 2 diabetes (T2D) in a Chinese population.
methodsA nested case-control study comprising 571 T2D cases and 571 matched controls was conducted within the Singapore Chinese Health Study. Alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), and lactate dehydrogenase (LDH) were quantified in baseline plasma collected from them, while γ-glutamyltransferase (GGT) was assayed among 255 T2D cases with baseline hemoglobin A1c <6.5% and 255 matched controls. Participants were free of diagnosed diabetes, cardiovascular disease, and cancer at blood collections (1999-2004). Incident self-reported T2D cases were identified at follow-up II interview (2006-2010). Controls were matched to cases on age, sex, dialect group, and date of blood collection.
resultsHigher levels of ALT and GGT were significantly associated with increased risk of T2D (p for trend <0.001 for ALT, p for trend=0.03 for GGT), and the ORs (95% CIs) comparing highest versus lowest tertiles of ALT and GGT were 2.00 (1.01 to 3.96) and 2.38 (1.21 to 4.66), respectively. A null association was observed for AST, ALP, and LDH with T2D risk. Adding GGT (<23 vs ≥23 IU/L) or ALT (<21 vs ≥21 IU/L) to a prediction model resulted in significant gain in net reclassification improvement and integrated discrimination improvement of T2D prediction (all p<0.001).
conclusionsHigher levels of GGT and ALT are associated with increased T2D risk. GGT ≥23 IU/L and ALT ≥21 IU/L may identify people at higher risk of developing T2D in this Chinese population.
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