Evidence map›Paper›PMID 27738386›Full record

ArticleMediators of inflammation2016

Serum Cytokines Th1, Th2, and Th17 Expression Profiling in Active Lupus Nephritis-IV: From a Southern Chinese Han Population.

Keshav Raj Sigdel, Lihua Duan, Yin Wang, Weiping Hu, Ning Wang, Qingyi Sun, Qingyan Liu, Xiaocong Liu, Xianghua Hou, Ao Cheng and 2 more

Open access · goldAbstract read
In one paragraph

Article in Mediators of inflammation, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 3 pooled it
3.6field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 3 syntheses or guidelines pooled it, 41 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. Article
  6. Review
  7. Immunometabolism in systemic lupus erythematosus.Nature reviews. Rheumatology · 2025
    Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Review
  15. Involvement of Inflammasome Components in Kidney Disease.Antioxidants (Basel, Switzerland) · 2022
    Review
  16. Review
  17. Article
  18. Article
  19. Article
  20. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Keshav Raj SigdelDepartment of Nephrology, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian, China; Department of Nephrology, The First Hospital of Xiamen, Fujian Medical University, Xiamen, China; Arogya Health Home, Arthritis and Rheumatic Diseases Treatment Center, Jawalakhel, Lalitpur, Nepal.ORCID 0000-0002-0832-2579
Lihua DuanDepartment of Rheumatology and Clinical Immunology, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian, China.ORCID 0000-0002-1631-4675
Yin WangDepartment of Nephrology, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian, China; Department of Nephrology, The First Hospital of Xiamen, Fujian Medical University, Xiamen, China.
Weiping HuDepartment of Nephrology, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian, China; Department of Nephrology, The First Hospital of Xiamen, Fujian Medical University, Xiamen, China.
Ning WangDepartment of Nephrology, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian, China; Department of Nephrology, The First Hospital of Xiamen, Fujian Medical University, Xiamen, China.
Qingyi SunDepartment of Nephrology, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian, China; Department of Nephrology, The First Hospital of Xiamen, Fujian Medical University, Xiamen, China.
Qingyan LiuDepartment of Nephrology, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian, China; Department of Nephrology, The First Hospital of Xiamen, Fujian Medical University, Xiamen, China.
Xiaocong LiuDepartment of Nephrology, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian, China; Department of Nephrology, The First Hospital of Xiamen, Fujian Medical University, Xiamen, China.
Xianghua HouDepartment of Nephrology, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian, China; Department of Nephrology, The First Hospital of Xiamen, Fujian Medical University, Xiamen, China.
Ao ChengDepartment of Nephrology, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian, China; Department of Nephrology, The First Hospital of Xiamen, Fujian Medical University, Xiamen, China.
Guixiu ShiDepartment of Rheumatology and Clinical Immunology, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian, China.ORCID 0000-0003-4044-3394
Yanlin ZhangDepartment of Nephrology, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian, China; Department of Nephrology, The First Hospital of Xiamen, Fujian Medical University, Xiamen, China.ORCID 0000-0002-7857-4173
Fujian Medical University · CNFirst Affiliated Hospital of Xiamen University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by aberrant T cell immune response. Diffuse proliferative lupus nephritis (LN-IV) is the most common, severe, and active form of lupus nephritis. In this study, we investigated the production of Th1, Th2, and Th17 cytokines in prediction of active form of LN-IV. ProcartaPlex multiplex immunoassays panels were used for detection of serum Th1, Th2, and Th17 cytokines profiling. Th1 and Th17 cytokines (IL-18, IFN-

Indexed as

AdultAsian PeopleComplement C3Complement C4CytokinesFemaleHumansInterferon-gammaInterleukin-12Interleukin-13Interleukin-18Interleukin-4Interleukin-6Lipocalin-2Lupus NephritisMaleComplement C3Complement C4CytokinesInterferon-gammaInterleukin-12Interleukin-13Interleukin-18Interleukin-4Interleukin-6Lipocalin-2Tumor Necrosis Factor-alpha

Identifiers

PMID27738386
PMCPMC5055982
OpenAlexW2522112604

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.