Evidence map›Paper›PMID 27738312›Full record

ArticleOncotarget2016

IL27 controls skin tumorigenesis via accumulation of ETAR-positive CD11b cells in the pre-malignant skin.

Denada Dibra, Abhisek Mitra, Melissa Newman, Xueqing Xia, Camille Keenan, Jeffry J Cutrera, J Michael Mathis, Xiao-Jing Wang, Jeffrey Myers, Shulin Li

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncotarget, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.3field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
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  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Denada DibraDepartment of Pediatrics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Abhisek MitraDepartment of Pediatrics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Melissa NewmanBanfield Pet Hospital, Sugar Land, TX 77479, USA.
Xueqing XiaDepartment of Pediatrics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Camille KeenanThe University of Texas Health Science Center at Houston, Medical School, Houston, TX 77030, USA.
Jeffry J CutreraDepartment of Pediatrics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
J Michael MathisDepartment of Comparative Biomedical Sciences, Louisiana State University School of Veterinary Medicine, Baton Rouge, LA 70803, USA.
Xiao-Jing WangDepartment of Pathology, University of Colorado Anschutz Medical School, Aurora, CO 80045, USA.
Jeffrey MyersDepartment of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Shulin LiDepartment of Pediatrics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
The University of Texas MD Anderson Cancer Center · USHouston Methodist Sugar Land Hospital · USLouisiana State University · USThe University of Texas Health Science Center at Houston · USUniversity of Colorado Anschutz Medical Campus · US

Funding

IL12 Gene Therapy For Enhancing Therapeutic Efficacy of Bleomycin Against Oral TuR01CA142855 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI LI, SHULIN · 2010 to 2014
$1.6M
NCI NIH HHS R01 CA142855
6 · The paper itself

Abstract

Establishment of a permissive pre-malignant niche in concert with mutant stem are key triggers to initiate skin carcinogenesis. An understudied area of research is finding upstream regulators of both these triggers. IL27, a pleiotropic cytokine with both pro- and anti-inflammatory properties, was found to be a key regulator of both. Two step skin carcinogenesis model and K15-KRASG12D mouse model were used to understand the role of IL27 in skin tumors. CD11b-/- mice and small-molecule of ETAR signaling (ZD4054) inhibitor were used in vivo to understand mechanistically how IL27 promotes skin carcinogenesis. Interestingly, using in vivo studies, IL27 promoted papilloma incidence primarily through IL27 signaling in bone-marrow derived cells. Mechanistically, IL27 initiated the establishment of the pre-malignant niche and expansion of mutated stem cells in K15-KRASG12D mouse model by driving the accumulation of Endothelin A receptor (ETAR)-positive CD11b cells in the skin-a novel category of pro-tumor inflammatory identified in this study. These findings are clinically relevant, as the number of IL27RA-positive cells in the stroma is highly related to tumor de-differentiation in patients with squamous cell carcinomas.

Indexed as

AnimalsCD11b AntigenInterleukinsMiceMutationProto-Oncogene Proteins p21(ras)PyrrolidinesReceptor, Endothelin AReceptors, CytokineReceptors, InterleukinSkin NeoplasmsStem Cell NicheCD11b AntigenHras protein, mouseIl27 protein, mouseIl27ra protein, mouseInterleukinsProto-Oncogene Proteins p21(ras)PyrrolidinesReceptor, Endothelin AReceptors, CytokineReceptors, InterleukinZD4054ET1/ETARIL27IL27RAinflammationKRAS

Identifiers

PMID27738312
PMCPMC5363575
OpenAlexW2531047724

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.