Evidence map›Paper›PMID 27738016›Full record

ArticleScience (New York, N.Y.)2016

RNA interference is essential for cellular quiescence.

B Roche, B Arcangioli, R A Martienssen

Open access · greenAbstract read
In one paragraph

Article in Science (New York, N.Y.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 69 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. RiboCop surveils pre-rRNA processing by Dicer in cellular quiescence.bioRxiv : the preprint server for biology · 2025
    Article
  6. Clr4Nature communications · 2024
    Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. AGO2 silences mobile transposons in the nucleus of quiescent cells.Nature structural & molecular biology · 2023
    Article
  14. The longevity and reversibility of quiescence inCell cycle (Georgetown, Tex.) · 2023
    Article
  15. Disruption of theRNA (New York, N.Y.) · 2023
    Article
  16. Review
  17. Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

B RocheHoward Hughes Medical Institute-Gordon and Betty Moore Foundation, Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA.
B ArcangioliDynamics of the Genome Unit, Department of Genomes and Genetics, Institut Pasteur, UMR3525, 25-28 rue du Docteur Roux, Paris 75015, France.
R A MartienssenHoward Hughes Medical Institute-Gordon and Betty Moore Foundation, Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA. martiens@cshl.edu.
Gordon and Betty Moore Foundation · USInstitut Pasteur · FR

Funding

RNAi, Histone Modification and the DDB1/CPSF-Like Complex Rik1R01GM076396 · NIGMS · COLD SPRING HARBOR LABORATORY · PI MARTIENSSEN, ROBERT A · 2007 to 2020
$4.9M
Howard Hughes Medical InstituteNIGMS NIH HHS R01 GM076396
6 · The paper itself

Abstract

Quiescent cells play a predominant role in most organisms. Here we identify RNA interference (RNAi) as a major requirement for quiescence (G

Indexed as

RNA InterferenceCentromereChromosomal Proteins, Non-HistoneChromosome SegregationDNA, RibosomalHeterochromatinMutationResting Phase, Cell CycleRibonuclease IIIRNA Polymerase IRNA Polymerase IISchizosaccharomycesSchizosaccharomyces pombe ProteinsChromosomal Proteins, Non-HistoneDNA, RibosomalHeterochromatinRibonuclease IIIRik1 protein, S pombeRNA Polymerase IRNA Polymerase IISchizosaccharomyces pombe Proteins

Identifiers

PMID27738016
PMCPMC5858868
OpenAlexW2530415702

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.