Evidence map›Paper›PMID 27738004›Full record

ArticleThe Journal of cell biology2016

GEF-H1 is necessary for neutrophil shear stress-induced migration during inflammation.

Noah Fine, Ioannis D Dimitriou, Jacob Rullo, María José Sandí, Björn Petri, Jack Haitsma, Hisham Ibrahim, Jose La Rose, Michael Glogauer, Paul Kubes and 2 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of cell biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 45 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Review
  14. Review
  15. Review
  16. Review
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Noah FinePrincess Margaret Cancer Center, Toronto, Ontario M5G 1L7, Canada Department of Medical Biophysics, University of Toronto, Toronto, Ontario M5S 1L7, Canada Matrix Dynamics Group, University of Toronto, Toronto, Ontario M5S 3E2, Canada.ORCID http://orcid.org/0000-0002-7234-094X
Ioannis D DimitriouPrincess Margaret Cancer Center, Toronto, Ontario M5G 1L7, Canada Department of Immunology, University of Toronto, Toronto, Ontario M5S 1L7, Canada.ORCID http://orcid.org/0000-0001-5778-8896
Jacob RulloToronto General Research Institute, University Health Network, Toronto, Ontario M5G 2C4, Canada.
María José SandíPrincess Margaret Cancer Center, Toronto, Ontario M5G 1L7, Canada.ORCID http://orcid.org/0000-0002-4782-3800
Björn PetriImmunology Research Group, Department of Physiology and Pharmacology, Calvin, Phoebe and Joan Snyder Institute for Infection, Immunity and Inflammation, University of Calgary, Calgary, Alberta T2N 4N1, Canada.ORCID http://orcid.org/0000-0002-5871-4132
Jack HaitsmaDepartment of Anesthesiology, VU Medical Center, 1081 HV Amsterdam, Netherlands.ORCID http://orcid.org/0000-0002-0738-9720
Hisham IbrahimToronto General Research Institute, University Health Network, Toronto, Ontario M5G 2C4, Canada.
Jose La RosePrincess Margaret Cancer Center, Toronto, Ontario M5G 1L7, Canada.
Michael GlogauerMatrix Dynamics Group, University of Toronto, Toronto, Ontario M5S 3E2, Canada.ORCID http://orcid.org/0000-0002-6248-5977
Paul KubesImmunology Research Group, Department of Physiology and Pharmacology, Calvin, Phoebe and Joan Snyder Institute for Infection, Immunity and Inflammation, University of Calgary, Calgary, Alberta T2N 4N1, Canada.
Myron CybulskyToronto General Research Institute, University Health Network, Toronto, Ontario M5G 2C4, Canada.ORCID http://orcid.org/0000-0002-1696-2867
Robert RottapelPrincess Margaret Cancer Center, Toronto, Ontario M5G 1L7, Canada Department of Medical Biophysics, University of Toronto, Toronto, Ontario M5S 1L7, Canada Department of Immunology, University of Toronto, Toronto, Ontario M5S 1L7, Canada Department of Medicine, University of Toronto, Toronto, Ontario M5S 1L7, Canada Toronto General Research Institute, University Health Network, Toronto, Ontario M5G 2C4, Canada rottapel@uhnresearch.ca.
University Health Network · CAUniversity of Toronto · CAPrincess Margaret Cancer Centre · CAUniversity of Calgary · CAAmsterdam UMC Location Vrije Universiteit Amsterdam · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Leukocyte crawling and transendothelial migration (TEM) are potentiated by shear stress caused by blood flow. The mechanism that couples shear stress to migration has not been fully elucidated. We found that mice lacking GEF-H1 (GEF-H1

Indexed as

Cell MovementStress, MechanicalAnimalsCell AdhesionHL-60 CellsHumansHuman Umbilical Vein Endothelial CellsInflammationMiceMicrotubulesModels, BiologicalMusclesMyosin Light ChainsNeutrophil InfiltrationNeutrophilsN-Formylmethionine Leucyl-PhenylalanineArhgef2 protein, mouseMyosin Light ChainsN-Formylmethionine Leucyl-PhenylalanineRho Guanine Nucleotide Exchange Factors

Identifiers

PMID27738004
PMCPMC5057286
OpenAlexW2530647269

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.