Evidence map›Paper›PMID 27737998›Full record

ArticleCanadian family physician Medecin de famille canadien2016

Primary care providers' experiences with and perceptions of personalized genomic medicine.

June C Carroll, Tutsirai Makuwaza, Donna P Manca, Nicolette Sopcak, Joanne A Permaul, Mary Ann O'Brien, Ruth Heisey, Elizabeth A Eisenhauer, Julie Easley, Monika K Krzyzanowska and 8 more

Registry-linked trialOpen access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in Canadian family physician Medecin de famille canadien, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04331535 (Pragmatic Randomized Trial of Polygenic Risk Scoring for Common Diseases in Primary Care), which is not on this map. Cited by 84 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
84citing papers in PubMed, 6 pooled it
11.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04331535 naunknown statusnot on this mapstarted 2020, after this paper: background citation

Pragmatic Randomized Trial of Polygenic Risk Scoring for Common Diseases in Primary Care

TypeinterventionalSponsorBoston VA Research Institute, Inc.Ran2020 to 2025Enrolled1,076ConditionsCoronary Artery Disease, Atrial Fibrillation, Type 2 Diabetes, Colorectal CancerArmsPolygenic risk score (PRS)
3 · Its place in the literature

Who cites it

84 citing papers in PubMed, 6 syntheses or guidelines pooled it, 117 citations in OpenAlex.

  1. Pooled it
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  5. Delivering genomic medicine in the United Kingdom National Health Service: a systematic review and narrative synthesis.Genetics in medicine : official journal of the American College of Medical Genetics · 2019
    Pooled it
  6. Genetic cancer risk assessment in general practice: systematic review of tools available, clinician attitudes, and patient outcomes.The British journal of general practice : the journal of the Royal College of General Practitioners · 2019
    Pooled it
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  19. Revolutionising Cardio-Oncology Care with Precision Genomics.International journal of molecular sciences · 2025
    Review
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24 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 14 institutions in 2 countries.

June C CarrollFamily physician in the Granovsky Gluskin Family Medicine Centre at Sinai Health System in Toronto, Ont, and Clinician Scientist and Professor in the Department of Family and Community Medicine at the University of Toronto. june.carroll@sinaihealthsystem.ca.
Tutsirai MakuwazaQualitative research assistant in the Departments of Family and Community Medicine, Sinai Health System, and at the University of Toronto.
Donna P MancaClinical Director of the Alberta Family Practice Research Network, Director of the Northern Alberta Primary Care Research Network, and Director of Research in the Department of Family Medicine at the University of Alberta in Edmonton.
Nicolette SopcakResearcher in the Department of Family Medicine at the University of Alberta.
Joanne A PermaulResearch associate in the Department of Family Medicine at Mount Sinai Hospital, Sinai Health System.
Mary Ann O'BrienAssistant Professor in the Department of Family and Community Medicine at the University of Toronto and Scientific Associate with the Knowledge Translation Research Network, Health Services Research Program, Ontario Institutefor Cancer Research.
Ruth HeiseyChief of the Department of Family and Community Medicine at Women's College Hospital in Toronto, a GP-oncologist at Princess Margaret Hospital in Toronto, and Clinician Investigator and Associate Professor in the Department of Family and Community Medicine at the University of Toronto.
Elizabeth A EisenhauerHead of the Department of Oncology at Queen's University in Kingston, Ont, Research Lead for the Canadian Partnership Against Cancer, and Co-Chair of the Canadian Cancer Research Alliance.
Julie EasleyResearch coordinator at the Dalhousie Family Medicine Teaching Unit in Fredericton, NB.
Monika K KrzyzanowskaMedical oncologist at Princess Margaret Cancer Centre in Toronto and Provincial Clinical Lead for Quality Care and Access within the Systemic Treatment Program at Cancer Care Ontario.
Baukje MiedemaProfessor and Director of Research at the Dalhousie Family Medicine Teaching Unit.
Sandhya PruthiConsultant in the Division of General Internal Medicine and Breast Diagnostic Clinic in the Department of Internal Medicine at the Mayo Clinic in Rochester, Minn.
Carol SawkaMedical oncologist and Adjunct Clinical Professor in the Department of Medicine at the University of Toronto and Adjunct Professor at the Institute of Health Policy, Management and Evaluation at the University of Toronto.
Nancy SchneiderRecently retired from a senior position with the Government of Alberta.
Jonathan SussmanRadiation oncologist and Clinician Scientist in the Department of Oncology at McMaster University in Hamilton, Ont, and Chair of the Survivorship Advisory Committee at Cancer Care Ontario.
Robin UrquhartAssistant Professor in the Department of Surgery, with a cross-appointment in the Department of Community Health and Epidemiology, at Dalhousie University in Halifax, NS, and is Senior Scientist at the Beatrice Hunter Cancer Research Institute in Halifax.
Catarina VersaevelSenior health care management consultant in Edmonton.
Eva GrunfeldGiblon Professor and Vice-Chair of Research in the Department of Family and Community Medicine at the University of Toronto and Director of Knowledge Translation Research in the Health Services Research Program at the Ontario Institute for Cancer Research.
Cancer Care Ontario · CADalhousie University · CAOntario Institute for Cancer Research · CASinai Health System · CAAlberta Health · CABeatrice Hunter Cancer Research Institute · CACanadian Partnership Against Cancer · CAGovernment of Alberta · CAInstitute of Health Economics · CAMayo Clinic · USMount Sinai Health System · USUniversity of Alberta · CAUniversity of Toronto · CAWomen's College Hospital · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo assess primary care providers' (PCPs') experiences with, perceptions of, and desired role in personalized medicine, with a focus on cancer.

designQualitative study involving focus groups.

settingUrban and rural interprofessional primary care team practices in Alberta and Ontario.

participantsFifty-one PCPs.

methodsSemistructured focus groups were conducted and audiorecorded. Recordings were transcribed and analyzed using techniques informed by grounded theory including coding, interpretations of patterns in the data, and constant comparison. MAIN

findingsFive focus groups with the 51 participants were conducted; 2 took place in Alberta and 3 in Ontario. Primary care providers described limited experience with personalized medicine, citing breast cancer and prenatal care as main areas of involvement. They expressed concern over their lack of knowledge, in some circumstances relying on personal experiences to inform their attitudes and practice. Participants anticipated an inevitable role in personalized medicine primarily because patients seek and trust their advice; however, there was underlying concern about the magnitude of information and pace of discovery in this area, particularly in direct-to-consumer personal genomic testing. Increased knowledge, closer ties to genetics specialists, and relevant, reliable personalized medicine resources accessible at the point of care were reported as important for successful implementation of personalized medicine.

conclusionPrimary care providers are prepared to discuss personalized medicine, but they require better resources. Models of care that support a more meaningful relationship between PCPs and genetics specialists should be pursued. Continuing education strategies need to address knowledge gaps including direct-to-consumer genetic testing, a relatively new area provoking PCP concern. Primary care providers should be mindful of using personal experiences to guide care.

Indexed as

Attitude of Health PersonnelGenomicsHealth Knowledge, Attitudes, PracticeAdultAgedAlbertaDirect-To-Consumer Screening and TestingFemaleFocus GroupsHealth PersonnelHumansInterviews as TopicMaleMiddle AgedNeoplasmsOntario

Identifiers

PMID27737998
PMCPMC5063789
OpenAlexW2533700582

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.