ArticleJournal of the renin-angiotensin-aldosterone system : JRAAS2016
Quantification of systemic renin-angiotensin system peptides of hypertensive black and white African men established from the RAS-Fingerprint®.
Article in Journal of the renin-angiotensin-aldosterone system : JRAAS, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
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- Circulating renin-angiotensin-aldosterone system markers in cats with non-hypertensive chronic kidney disease or systemic arterial hypertension.Journal of veterinary internal medicine · 2026Article
- Comparisons of renin-angiotensin-aldosterone levels measured by chemical luminescence immunoassay and liquid chromatography-tandem mass spectrometry in hypertensive patients under different pathophysiological conditions.Journal of human hypertension · 2025Article
- Post hoc comparison of the intrarenal and circulating renin-angiotensin(-aldosterone) systems in cats with ischemia-induced chronic kidney disease.Physiological reports · 2025Article
- Genomic Exploration of Essential Hypertension in African-Brazilian Quilombo Populations: A Comprehensive Approach With Pedigree Analysis and Family-Based Association Studies.Journal of the American Heart Association · 2025Article
- Angiotensin Dysregulation in Patients with Arterial Aneurysms.International journal of molecular sciences · 2025Article
- Advances in the biochemical diagnostics of primary aldosteronism: from immunoassays to steroidomics and proteomics.Frontiers in endocrinology · 2025Review
- [Hypertensive emergencies at Bogodogo University Hospital, Ouagadougou (Burkina Faso)].Medecine tropicale et sante internationale · 2024Article
- Association of Elevated Serum Aldosterone Concentrations in Pregnancy with Hypertension.Biomedicines · 2023Article
- Activation of the Renin-Angiotensin-Aldosterone System Is Attenuated in Hypertensive Compared with Normotensive Pregnancy.International journal of molecular sciences · 2023Article
- Poor Performance of Angiotensin II Enzyme-Linked Immuno-Sorbent Assays in Mostly Hypertensive Cohort Routinely Screened for Primary Aldosteronism.Diagnostics (Basel, Switzerland) · 2022Article
- Characterization of the intrarenal renin-angiotensin system in cats with naturally occurring chronic kidney disease.Journal of veterinary internal medicine · 2022Article
- Male bias in ACE2 basic science research: missed opportunity for discovery in the time of COVID-19.American journal of physiology. Regulatory, integrative and comparative physiology · 2021Review
- Stimulation of Angiotensin Converting Enzyme 2: A Novel Treatment Strategy for Diabetic Nephropathy.Frontiers in physiology · 2021Review
- Uncontrolled hypertension in sub-Saharan Africa: Now is the time to address a looming crisis.Journal of clinical hypertension (Greenwich, Conn.) · 2020Article
- Responses of the renin-angiotensin-aldosterone system in pregnant chronic kidney disease patients with and without superimposed pre-eclampsia.Clinical kidney journal · 2019Article
- Genetics of Hypertension in African Americans and Others of African Descent.International journal of molecular sciences · 2019Review
- Activation of the Human Angiotensin-(1-12)-Chymase Pathway in Rats With Human Angiotensinogen Gene Transcripts.Frontiers in cardiovascular medicine · 2019Article
- Association between preterm birth and the renin-angiotensin system in adolescence: influence of sex and obesity.Journal of hypertension · 2018Article
- Overexpression of the neuronal human (pro)renin receptor mediates angiotensin II-independent blood pressure regulation in the central nervous system.American journal of physiology. Heart and circulatory physiology · 2018Article
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Authors and funding
10 authors.
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Abstract
objectiveThe objective of this study was to make use of a quantitative and qualitative approach comparing the systemic renin-angiotensin system (RAS) of hypertensive black and white African men by using RAS equilibrium analysis. MATERIALS AND
methodsThis sub-study involved 23 black (n = 15) and white (n = 8) hypertensive men aged 39.5-41 years, living in the North West Province of South Africa. The RAS-Fingerprinting was determined with LC-MS/MS quantification of angiotensin peptides. Blood pressure and other variables were determined with known methods.
resultsThe main finding of this study was the significant lower Ang I (<5.0 and 45.1 pg/ml; p = 0.005) and Ang II (15.6 and 123.9 pg/ml; p ⩽ 0.001) encountered in the hypertensive black African men compared to their white counterparts. Levels of Ang 1-5 (downstream metabolite of Ang 1-7) (1.8 and 3.0 pg/ml), were detected in black and white hypertensive men, respectively.
conclusionsThe observed differences between circulating RAS components, which are reflected via equilibrium angiotensin levels, point to a distinctive molecular regulation of the RAAS in the two study cohorts. The increased peripheral resistance observed in hypertensive black individuals might take over a dominant role in control of blood pressure in this study population. A novel highly sensitive LC-MS/MS method resolved the issue of peptide recovery variations during sample preparation by using internal standards for each individual angiotensin metabolite.
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