Evidence map›Paper›PMID 27737774›Full record

Trial reportResuscitation2016

Exploring the safety and efficacy of targeted temperature management amongst infants with out-of-hospital cardiac arrest due to apparent life threatening events.

Kathleen Meert, Russell Telford, Richard Holubkov, Beth S Slomine, James R Christensen, J Michael Dean, Frank W Moler, Therapeutic Hypothermia after Paediatric Cardiac Arrest (THAPCA) Trial Investigators

Registry-linked trialOpen access · greenAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Resuscitation, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00878644 (Therapeutic Hypothermia After Pediatric Cardiac Arrest), which is not on this map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00878644 phase3completednot on this map

Therapeutic Hypothermia After Pediatric Cardiac Arrest (Out of Hospital)

TypeinterventionalSponsorUniversity of MichiganRan2009 to 2014Enrolled295ConditionsCardiac ArrestArmsTherapeutic Hypothermia, Therapeutic Normothermia
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Pooled it
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Kathleen MeertChildren's Hospital of Michigan, Wayne State University, 3901 Beaubien Boulevard, Detroit, MI 48201, USA. Electronic address: kmeert@med.wayne.edu.
Russell TelfordUniversity of Utah, 295 Chipeta Way, P. O. Box 581289, Salt Lake City, UT 84158, USA.
Richard HolubkovUniversity of Utah, 295 Chipeta Way, P. O. Box 581289, Salt Lake City, UT 84158, USA.
Beth S SlomineKennedy Krieger Institute, Johns Hopkins University, 707 North Broadway, Baltimore, MD 21205, USA.
James R ChristensenKennedy Krieger Institute, Johns Hopkins University, 707 North Broadway, Baltimore, MD 21205, USA.
J Michael DeanUniversity of Utah, 295 Chipeta Way, P. O. Box 581289, Salt Lake City, UT 84158, USA.
Frank W MolerUniversity of Michigan, CS Mott Children's Hospital, 1540 East Hospital Drive, Ann Arbor, MI 48109, USA.
Therapeutic Hypothermia after Paediatric Cardiac Arrest (THAPCA) Trial Investigators
University of Utah · USKennedy Krieger Institute · USUniversity of Michigan · USWayne State University · US

Funding

Data Coordinating Center for the Collaborative Pediatric Critical Care Research NetworkU01HD049934 · NICHD · UNIVERSITY OF UTAH · PI DEAN, JONATHAN MICHAEL · 2005 to 2020
$35.2M
THAPCA Trials - Scientific ApplicationU01HL094345 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MOLER, FRANK W · 2009 to 2016
$12.7M
THAPCA Trials - DCC ApplicationU01HL094339 · NHLBI · UNIVERSITY OF UTAH · PI DEAN, JONATHAN MICHAEL · 2009 to 2015
$7.4M
Physiologically Guided Ventilator Strategies in ChildrenU10HD050012 · NICHD · CHILDREN'S HOSPITAL OF LOS ANGELES · PI NEWTH, CHRISTOPHER JOHN · 2005 to 2014
$3.7M
Neurodevelopmental Outcome after Cardiac Intensive CareU10HD049981 · NICHD · CHILDREN'S RESEARCH INSTITUTE · PI WESSEL, DAVID LLOYD · 2005 to 2014
$3.7M
Collaborative Pediatric Critical Care Research NetworkU10HD050096 · NICHD · WAYNE STATE UNIVERSITY · PI MEERT, KATHLEEN L. · 2005 to 2014
$3.2M
Metoclopramide prevents PICU nosocomial infectionU10HD049983 · NICHD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CARCILLO, JOSEPH A · 2005 to 2014
$3.1M
Collaborative Pediatric Critical Care Research NetworkUG1HD050096 · NICHD · WAYNE STATE UNIVERSITY · PI MEERT, KATHLEEN L. · 2015 to 2020
$1.6M
1st Tier Drugs+Theophylline in Pediatric Severe AsthmaU10HD049945 · NICHD · SEATTLE CHILDREN'S HOSPITAL · PI ZIMMERMAN, JERRY JOHN · 2005 to 2010
$1.6M
Collaborative Pediatric Critical Care Research Network - Clinical SiteRL1HD107773 · NICHD · CENTRAL MICHIGAN UNIVERSITY · PI KATHLEEN L. MEERT · 2021 to 2026
$862k
Hypothermia for Pediatric Cardiac Arrest Planning GrantR21HD044955 · NICHD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MOLER, FRANK W · 2003 to 2004
$306k
Planning Hypothermia Trial for Pediatric Cardiac ArrestR34HD050531 · NICHD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MOLER, FRANK W · 2006 to 2006
$189k
NHLBI NIH HHS U01 HL094339NHLBI NIH HHS U01 HL094345NICHD NIH HHS R21 HD044955NICHD NIH HHS R34 HD050531NICHD NIH HHS RL1 HD107773NICHD NIH HHS U01 HD049934NICHD NIH HHS U10 HD049945NICHD NIH HHS U10 HD049981NICHD NIH HHS U10 HD049983NICHD NIH HHS U10 HD050012NICHD NIH HHS U10 HD050096NICHD NIH HHS UG1 HD050096
6 · The paper itself

Abstract

objectiveTo explore the safety and efficacy of targeted temperature management amongst infants with out-of-hospital cardiac arrest due to an apparent life threatening event (ALTE) recruited to the Therapeutic Hypothermia after Paediatric Cardiac Arrest Out-of-Hospital trial.

methodsFifty-four infants (48h to <1year of age) with ALTE who received chest compressions for ≥2min, were comatose, and required mechanical ventilation after return of circulation were included. Infants were randomised to therapeutic hypothermia (33°C) (n=26) or therapeutic normothermia (36.8°C) (n=28) within six hours of return of circulation. Outcomes included 12-month survival with Vineland Adaptive Behaviour Scales, Second Edition (VABS-II) score ≥70, 12-month survival, change in VABS-II score from pre-arrest to 12 months post-arrest, and select safety measures.

resultsAmongst infants with pre-arrest VABS-II ≥70 (n=52), there was no difference in 12-month survival with VABS-II ≥70 between therapeutic hypothermia and therapeutic normothermia groups (2/25 (8.0%) vs. 1/27 (3.7%); relative risk 2.16; 95% confidence interval 0.21-22.38, p=0.60). Amongst all evaluable infants (n=53), the change in VABS-II score from pre-arrest to 12 months post-arrest did not differ (p=0.078) between therapeutic hypothermia and therapeutic normothermia groups, nor did 12-month survival (5/26 (19.2%) vs. 1/27 (3.7%); relative risk 5.19; 95% confidence interval 0.65-41.50, p=0.10).

conclusionsMortality was high amongst infants that were comatose after out-of-hospital cardiac arrest due to ALTE in both therapeutic hypothermia and therapeutic normothermia treated groups. Functional status was markedly reduced among survivors. (ClinicalTrials.gov, NCT00878644).

Indexed as

Cardiopulmonary ResuscitationComaFemaleHeart MassageHumansHypothermia, InducedInfantMaleOut-of-Hospital Cardiac ArrestTreatment OutcomeApparent life threatening eventCardiac arrestFunctional outcomeMortalitySudden infant death syndromeTherapeutic hypothermia

Identifiers

PMID27737774
PMCPMC5124384
OpenAlexW2530730366

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.