ArticleJournal of neuroinflammation2016
IL-10 plays an important role in the control of inflammation but not in the bacterial burden in S. epidermidis CNS catheter infection.
Article in Journal of neuroinflammation, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 38 citations in OpenAlex.
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- The Utility of Synovial Fluid Interleukin-10 in Diagnosing Chronic Periprosthetic Joint Infection: A Prospective Cohort Study.Infection and drug resistance · 2025Article
- Peripheral white blood cell patterns in children with hydrocephalus as a response to ventriculo-peritoneal shunt infection.PloS one · 2024Article
- C1q is elevated during chronicFrontiers in immunology · 2024Article
- IL-10 production by granulocytes promotes Staphylococcus aureus craniotomy infection.Journal of neuroinflammation · 2023Article
- Immune mediating molecules and pathogenesis of COVID-19-associated neurological disease.Microbial pathogenesis · 2021Review
- Comparison of Host Cytokine Response in Piglets Infected With Toxigenic and Non-toxigenicFrontiers in veterinary science · 2021Article
- The Regulatory Role of IL-10 in Neurodegenerative Diseases.Biomolecules · 2020Review
- Inflammation in acquired hydrocephalus: pathogenic mechanisms and therapeutic targets.Nature reviews. Neurology · 2020Review
- Cytokine Levels in thePolish journal of microbiology · 2019Article
- Identification of Potential Cerebrospinal Fluid Biomarkers To Discriminate between Infection and Sterile Inflammation in a Rat Model of Staphylococcus epidermidis Catheter Infection.Infection and immunity · 2019Article
- CSF inflammatory markers differ in gram-positive versus gram-negative shunt infections.Journal of neuroinflammation · 2019Article
- Unexpected eosinophilia in children affected by hydrocephalus accompanied with shunt infection.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2018Article
- The Interleukin-10 Family of Cytokines and Their Role in the CNS.Frontiers in cellular neuroscience · 2018Review
- Pathogenic Mechanisms and Host Interactions inFrontiers in microbiology · 2017Review
- Systemic Administration of Lipopolysaccharide fromIn vivo (Athens, Greece)Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundShunt infection is a frequent and serious complication in the surgical treatment in hydrocephalus. Previous studies have shown an attenuated immune response to these biofilm-mediated infections. We proposed that IL-10 reduces the inflammatory response to Staphylococcus epidermidis (S. epidermidis) CNS catheter infection.
methodsIn this study, a murine model of catheter-associated S. epidermidis biofilm infection in the CNS was generated based on a well-established similar model for S. aureus. The catheters were pre-coated with a clinically derived biofilm-forming strain of S. epidermidis (strain 1457) which were then stereotactically implanted into the lateral left ventricle of 8-week-old C57BL/6 and IL-10 knockout (IL-10 knockout) mice. Bacterial titers as well as cytokine and chemokine levels were measured at days 3, 5, 7, and 10 in mice implanted with sterile and S. epidermidis-coated catheters.
resultsCultures demonstrated a catheter-associated and parenchymal infection that persisted through 10 days following infection. Cytokine analysis of the tissue surrounding the catheters revealed greater levels of IL-10, an anti-inflammatory cytokine, in the infected group compared to the sterile. In IL-10 KO mice, we noted no change in bacterial burdens, showing that IL-10 is not needed to control the infection in a CNS catheter infection model. However, IL-10 KO mice had increased levels of pro-inflammatory mediators in the tissues immediately adjacent to the infected catheter, as well as an increase in weight loss.
conclusionsTogether our results indicate that IL-10 plays a key role in regulating the inflammatory response to CNS catheter infection but not in control of bacterial burdens. Therefore, IL-10 may be a useful therapeutic target for immune modulation in CNS catheter infection but this should be used in conjunction with antibiotic therapy for bacterial eradication.
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