Trial reportCritical care (London, England)2016
Risk factors, host response and outcome of hypothermic sepsis.
Trial report in Critical care (London, England), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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The trial behind it
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Who cites it
40 citing papers in PubMed, 97 citations in OpenAlex.
- Fever and hypothermia represent two populations of sepsis patients and are associated with outside temperature.Critical care (London, England) · 2021Trial
- Dissipation of the mitochondrial proton motive force drives sepsis pathogenesis and explains hyperlactatemia's predictive value in sepsis mortality.World journal of critical care medicine · 2026Review
- Association between early body temperature dynamic trajectory and mortality and infection rates for patients with cardiac arrest in ICU: a retrospective study.Journal of thoracic disease · 2026Article
- The poikilothermic hypothesis of sepsis.Critical care (London, England) · 2026Review
- Machine learning prediction of early hypothermia in sepsis patients.Archives of medical science : AMS · 2026Article
- Relation between initial hypothermia, course of the hypothermia and mortality in patients with septic shock: a post-hoc analysis of the SEPSISPAM randomized trial.Annals of intensive care · 2026Article
- Development of a Scoring System to Predict the Treatment Success for Nonoperative Management of Peptic Ulcer Perforation: A Secondary Data Analysis of PPAP Study.Annals of gastroenterological surgery · 2026Article
- Temperature profiles in adult intensive care unit patients treated for infection in a tertiary intensive care unit: A single-centre prospective observational cohort study.Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine · 2025Article
- Association of Modifiable Lifestyle and Metabolic Factors With the Risk of Developing Sepsis: 2-Sample Mendelian Randomized Study.Interactive journal of medical research · 2025Article
- Clinical characteristics associated with septic shock complicating hypothermia: a retrospective cohort study from the MIMIC-IV database.European journal of medical research · 2025Article
- Early body temperature trajectories and short term prognosis in sepsis associated acute kidney injury.Scientific reports · 2025Article
- Development and validation of a LASSO-based predictive model for inadvertent hypothermia in ICU patients.Frontiers in medicine · 2025Article
- Triage body temperature predicts outcome in cats at emergency department admission: a retrospective study of 1440 cases (January 2018 to December 2021).Journal of feline medicine and surgery · 2025Article
- Association between body temperature and all-cause mortality in patients with sepsis: analysis of the MIMIC-IV database.European journal of medical research · 2024Article
- What Clinicians Think About When They Think About Sepsis: Results From a Survey Across the University of Maryland Medical System.Critical care explorations · 2024Article
- Modern CRRT systems are associated with lower risk of hypothermia.Scientific reports · 2024Observational
- Lanthanide luminescence nanothermometer with working wavelength beyond 1500 nm for cerebrovascular temperature imaging in vivo.Nature communications · 2024Article
- Article
- Host Response in Critically Ill Patients Aged 65 Years or Older: A Prospective Study.Clinical interventions in aging · 2024Article
- Clinical Sepsis Phenotypes in Critically Ill Patients.Microorganisms · 2023Review
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Authors and funding
13 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHypothermia is associated with adverse outcome in patients with sepsis. The objective of this study was to characterize the host immune response in patients with hypothermic sepsis in order to determine if an excessive anti-inflammatory response could explain immunosuppression and adverse outcome. Markers of endothelial activation and integrity were also measured to explore potential alternative mechanisms of hypothermia. Finally we studied risk factors for hypothermia in an attempt to find new clues to the etiology of hypothermia in sepsis.
methodsConsecutive patients diagnosed with sepsis within 24 hours after admission to ICUs in two tertiary hospitals in the Netherlands were included in the study (n = 525). Hypothermia was defined as body temperature below 36 °C in the first 24 h of ICU admission.
resultsHypothermia was identified in 186 patients and was independently associated with mortality. Levels of proinflammatory and anti-inflammatory cytokines were not different between groups. Hypothermia was also not associated with an altered response to ex vivo stimulation with lipopolysaccharide in a subset of 15 patients. Risk factors for hypothermia included low body mass index, hypertension and chronic cardiovascular insufficiency. Levels of the endothelial activation marker fractalkine were increased during the first 4 days of ICU stay.
conclusionsHypothermia during sepsis is independently associated with mortality, which cannot be attributed to alterations in the host immune responses that were measured in this study. Given that risk factors for hypothermic sepsis are mainly cardiovascular and that the endothelial activation marker fractalkine increased in hypothermia, these findings may suggest that vascular dysfunction plays a role in hypothermic sepsis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.