ArticleBMC veterinary research2016
Tissue expression and antibacterial activity of host defense peptides in chicken.
Article in BMC veterinary research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 63 citations in OpenAlex.
- Chicken cathelicidin-3 protected mice from avian pathogenic Escherichia coli infection mediated by triggering chemokine CCL3 pathway.Veterinary research · 2026Article
- Evaluating the Immunogenicity and Protective Efficacy of a Novel Vaccine Candidate AgainstVaccines · 2026Article
- Time-course analysis of the effect of paraprobiotics ABG0050 on the intestinal immune system of broilers.Poultry science · 2025Article
- Dietary apidaecin Api-PR19 addition enhances growth performance by regulating gut health and microbiota in broilers.Animal bioscience · 2024Article
- Immunomodulatory properties of chicken cathelicidin-2 investigated on an ileal explant culture.Veterinary research communications · 2024Article
- Establishment of a Steatosis Model in LMH Cells, Chicken Embryo Hepatocytes, and Liver Tissues Based on a Mixture of Sodium Oleate and Palmitic Acid.Animals : an open access journal from MDPI · 2024Article
- Protamine cleavage specificity of the avian pathogenFrontiers in veterinary science · 2024Article
- Transcriptome analysis of Corvus splendens reveals a repertoire of antimicrobial peptides.Scientific reports · 2023Article
- The protective role of chicken cathelicidin-1 against Streptococcus suis serotype 2 in vitro and in vivo.Veterinary research · 2023Article
- Dietary Soy Saponin Improves Antioxidant and Immune Function of Layer Hens.The journal of poultry science · 2022Article
- Delay of Feed Post-Hatch Causes Changes in Expression of Immune-Related Genes and Their Correlation with Components of Gut Microbiota, but Does Not Affect Protein Expression.Animals : an open access journal from MDPI · 2022Article
- Toll-Like Receptors Signaling Pathway of Quercetin Regulating Avian Beta-Defensin in the Ileum of Broilers.Frontiers in cell and developmental biology · 2022Article
- Benefit of Dietary Supplementation with Bacillus subtilis BYS2 on Growth Performance, Immune Response, and Disease Resistance of Broilers.Probiotics and antimicrobial proteins · 2020Article
- Effects of ProbioticsThe journal of poultry science · 2020Article
- Induction of Chicken Host Defense Peptides within Disease-Resistant and -Susceptible Lines.Genes · 2020Article
- Chicken avian β-defensin 8 modulates immune response via the mitogen-activated protein kinase signaling pathways in a chicken macrophage cell line.Poultry science · 2020Article
- Molecular characterization, mRNA gene expression, and antimicrobial activity of 2 new cathelicidin genes in goose.Poultry science · 2020Article
- The Control of Intestinal Inflammation: A Major Objective in the Research of Probiotic Strains as Alternatives to Antibiotic Growth Promoters in Poultry.Microorganisms · 2020Review
- Article
- Cathelicidin Host Defense Peptides and Inflammatory Signaling: Striking a Balance.Frontiers in microbiology · 2020Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHost defence peptides are a diverse group of small, cationic peptides and are important elements of the first line of defense against pathogens in animals. Expression and functional analysis of host defense peptides has been evaluated in chicken but there are no direct, comprehensive comparisons with all gene family and individual genes.
resultsWe examined the expression patterns of all known cathelicidins, β-defensins and NK-lysin in multiple selected tissues from chickens. CATH1 through 3 were predominantly expressed in the bone marrow, whereas CATHB1 was predominant in bursa of Fabricius. The tissue specific pattern of β-defensins generally fell into two groups. β-defensin1-7 expression was predominantly in bone marrow, whereas β-defensin8-10 and β-defensin13 were highly expressed in liver. NK-lysin expression was highest in spleen. We synthesized peptide products of these gene families and analysed their antibacterial efficacy. Most of the host defense peptides showed antibacterial activity against E.coli with dose-dependent efficacy. β-defensin4 and CATH3 displayed the strongest antibacterial activity among all tested chicken HDPs. Microscopic analyses revealed the killing of bacterium by disrupting membranes with peptide treatment.
conclusionsThese results demonstrate dose-dependent antimicrobial effects of chicken HDPs mediated by membrane damage and demonstrate the differential tissue expression pattern of bioactive HDPs in chicken and the relative antimicrobial potency of the peptides they encode.
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