ArticleBMC infectious diseases2016
Human Puumala hantavirus infection in northern Sweden; increased seroprevalence and association to risk and health factors.
Article in BMC infectious diseases, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Occupational Hantavirus Infections in Agricultural and Forestry Workers: A Systematic Review and Metanalysis.Viruses · 2021Pooled it
- Design and in silico evaluation of PV-GNProtecta: an mRNA multi-epitope vaccine candidate against Puumala virus using immunoinformatics and structural analysis.Genomics & informatics · 2026Article
- Article
- Seroprevalence of Hantavirus among Manual Cane Cutters and Epidemiological Aspects of HPS in Central Brazil.Viruses · 2023Article
- Hemorrhagic Fever with Renal Syndrome in Asia: History, Pathogenesis, Diagnosis, Treatment, and Prevention.Viruses · 2023Review
- Article
- Clinical and genomic characterisation of a fatal Puumala orthohantavirus case with low levels of neutralising antibodies.Infectious diseases (London, England) · 2022Article
- Long-Term Consequences of Puumala Hantavirus Infection.Viruses · 2022Article
- Influence of Climatic Factors on Human Hantavirus Infections in Latin America and the Caribbean: A Systematic Review.Pathogens (Basel, Switzerland) · 2021Review
- Hantaviruses in Agricultural and Forestry Workers: Knowledge, Attitudes and Practices in Italian Physicians.Tropical medicine and infectious disease · 2021Article
- Prevalence of Orthohantavirus-Reactive Antibodies in Humans and Peri-Domestic Rodents in Northern Ethiopia.Viruses · 2021Article
- Cystatin C and α-1-Microglobulin Predict Severe Acute Kidney Injury in Patients with Hemorrhagic Fever with Renal Syndrome.Pathogens (Basel, Switzerland) · 2020Article
- Epidemiologic Characteristics of Domestic Patients with Hemorrhagic Fever with Renal Syndrome in Taiwan: A 19-Year Retrospective Study.International journal of environmental research and public health · 2020Article
- Innate and adaptive immune responses against human Puumala virus infection: immunopathogenesis and suggestions for novel treatment strategies for severe hantavirus-associated syndromes.Journal of internal medicine · 2019Review
- Vaccines and Therapeutics Against Hantaviruses.Frontiers in microbiology · 2019Review
- Genetic characterization of a hantavirus isolated from Heilongjiang province, China.Canadian journal of veterinary research = Revue canadienne de recherche veterinaire · 2019Article
- Preliminary insights into the genetics of bank vole tolerance to Puumala hantavirus in Sweden.Ecology and evolution · 2018Article
- Population-based seroprevalence of Puumala hantavirus in Finland: smoking as a risk factor.Epidemiology and infection · 2018Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe rodent borne Puumala hantavirus (PUUV) causes haemorrhagic fever with renal syndrome in central and northern Europe. The number of cases has increased and northern Sweden has experienced large outbreaks in 1998 and 2006-2007 which raised questions regarding the level of immunity in the human population.
methodsA randomly selected population aged between 25 and 74 years from northern Sweden were invited during 2009 to participate in a WHO project for monitoring of trends and determinants in cardiovascular disease. Health and risk factors were evaluated and sera from 1,600 participants were available for analysis for specific PUUV IgG antibodies using a recombinant PUUV nucleocapsid protein ELISA.
resultsThe overall seroprevalence in the investigated population was 13.4 %, which is a 50 % increase compared to a similar study only two decades previously. The prevalence of PUUV IgG increased with age, and among 65-75 years it was 22 %. More men (15.3 %) than women (11.4 %) were seropositive (p < 0.05). The identified risk factors were smoking (OR = 1.67), living in rural areas (OR = 1.92), and owning farmland or forest (OR = 2.44). No associations were found between previous PUUV exposure and chronic lung disease, diabetes, hypertension, renal dysfunction, stroke or myocardial infarction.
conclusionsPUUV is a common infection in northern Sweden and there is a high life time risk to acquire PUUV infection in endemic areas. Certain risk factors as living in rural areas and smoking were identified. Groups with increased risk should be targeted for future vaccination when available, and should also be informed about appropriate protection from rodent secreta.
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