Observational studyBMC infectious diseases2016
Hemoglobin levels and blood transfusion in patients with sepsis in Internal Medicine Departments.
Observational study in BMC infectious diseases, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
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Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 69 citations in OpenAlex.
- Guideline
- The Efficacy of Whole Blood Exchange-Lymphoplasmapheresis Combined with Transfusion in Sepsis with Anemia.Shock (Augusta, Ga.) · 2026Article
- Red Blood Cell Transfusion Beyond Restrictive Thresholds in Patients With Septic Shock and an Elevated Lactate Level: A Multicenter Observational Study.Journal of Korean medical science · 2026Observational
- Observational
- Negative association of hemoglobin levels with mortality in older Japanese patients with dysphagia: a retrospective cohort study.Frontiers in medicine · 2026Article
- Association of hemoglobin level trajectories with clinical outcomes in patients with sepsis or shock: a retrospective observational study.BMC infectious diseases · 2025Observational
- Platelet-to-hemoglobin ratio as a novel prognostic biomarker in sepsis-associated AKI: a multicenter cohort study.BMC nephrology · 2025Article
- Machine learning algorithms for risk factor selection with application to 60-day sepsis morbidity risk for a geriatric hip fracture cohort.BMC geriatrics · 2025Article
- The relationship between hemoglobin, albumin, lymphocyte, and platelet (HALP) score and 28-day mortality in patients with sepsis: a retrospective analysis of the MIMIC-IV database.BMC infectious diseases · 2025Article
- Exploration of the Clinical Parameters as Predictive Biomarkers and Their Potential Roles in the Regulation of Inflammation in Elderly Septic Patients with Pneumonia.Journal of inflammation research · 2025Article
- Association between HALP score and in-hospital mortality in sepsis patients: a multicenter retrospective cohort study with external validation.Frontiers in public health · 2025Article
- Association between hemoglobin and in-hospital mortality in critically ill patients with sepsis: evidence from two large databases.BMC infectious diseases · 2024Article
- Relationship between the magnitude of haemoglobin changes and long-term mortality in patients with sepsis: a retrospective cohort study.BMC infectious diseases · 2024Article
- Association between admission hemoglobin level and prognosis in sepsis patients based on a critical care database.Scientific reports · 2024Article
- The critically ill older patient with sepsis: a narrative review.Annals of intensive care · 2024Review
- Article
- Elevated circulating PCSK9 level is associated with 28-day mortality in patients with sepsis: a prospective cohort study.BMC emergency medicine · 2023Article
- The correlation of hemoglobin and 28-day mortality in septic patients: secondary data mining using the MIMIC-IV database.BMC infectious diseases · 2023Article
- Machine learning models for prediction of invasion Klebsiella pneumoniae liver abscess syndrome in diabetes mellitus: a singled centered retrospective study.BMC infectious diseases · 2023Article
- Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAcute reduction in hemoglobin levels is frequently seen during sepsis. Previous studies have focused on the management of anemia in patients with septic shock admitted to intensive care units (ICU's), including aggressive blood transfusion aiming to enhance tissue oxygenation.
aimTo study the changes in hemoglobin concentrations during the first week of sepsis in the setting of Internal Medicine (IM) units, and their correlation to survival.
designObservational prospective study.
methodsWe recorded hemoglobin values upon admission and throughout the first week of hospital stay in a consecutive cohort of septic patients admitted to IM units at a community hospital, the patients were enrolled into a prospective registry. Data on blood transfusions was also collected, we examined the correlation between hemoglobin concentrations during the first week of sepsis and survival, the effect of blood transfusion was also assessed.
resultsEight hundred and fifteen patients (815) with sepsis were enrolled between February 2008 to January 2009. More than 20 % of them had hemoglobin levels less than 10g/dL on admission, a rate that was doubled during the first week of sepsis. Overall, 68 (8.3 %) received blood transfusions, 14 of them (20.6 %) due to bleeding. Typically, blood transfusion was given to older patients with a higher rate of malignancy and lower hemoglobin levels. While hemoglobin concentration on admission had strong correlation with in-hospital mortality (O.R-0.83 [95 % C.I. 0.74-0.92], blood transfusion was not found to be an independent predicting factor for mortality.
conclusionAnemia is very common in sepsis. While hemoglobin level on admission exhibit independent correlation with survival, blood transfusion do not.
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