ArticleHuman biology2015
A General Model of the Relationship between the Apportionment of Human Genetic Diversity and the Apportionment of Human Phenotypic Diversity.
Article in Human biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Article
- Error rates in QST-FST comparisons depend on genetic architecture and estimation procedures.Genetics · 2025Article
- scAI-SNP: a method for inferring ancestry from single-cell data.BMC methods · 2025Article
- Error rates inbioRxiv : the preprint server for biology · 2024Article
- Heritability within groups is uninformative about differences among groups: Cases from behavioral, evolutionary, and statistical genetics.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Heritability within groups is uninformative about differences among groups: cases from behavioral, evolutionary, and statistical genetics.bioRxiv : the preprint server for biology · 2024Article
- The background and legacy of Lewontin's apportionment of human genetic diversity.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Review
- Diversity and its causes: Lewontin on racism, biological determinism and the adaptationist programme.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Review
- Population differentiation of polygenic score predictions under stabilizing selection.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Article
- Enrichment analyses identify shared associations for 25 quantitative traits in over 600,000 individuals from seven diverse ancestries.American journal of human genetics · 2022Article
- Skin deep: The decoupling of genetic admixture levels from phenotypes that differed between source populations.American journal of physical anthropology · 2021Article
- The evolution of group differences in changing environments.PLoS biology · 2021Article
- The Phenotypic Consequences of Genetic Divergence between Admixed Latin American Populations: Antioquia and Chocó, Colombia.Genome biology and evolution · 2020Article
- Evolutionary perspectives on polygenic selection, missing heritability, and GWAS.Human genetics · 2020Review
- The Effects of Demography and Genetics on the Neutral Distribution of Quantitative Traits.Genetics · 2019Article
- Interpreting polygenic scores, polygenic adaptation, and human phenotypic differences.Evolution, medicine, and public health · 2019Review
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2 authors.
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Abstract
Models that examine genetic differences between populations alongside a genotype-phenotype map can provide insight about phenotypic variation among groups. We generalize a simple model of a completely heritable, additive, selectively neutral quantitative trait to examine the relationship between single-locus genetic differentiation and phenotypic differentiation on quantitative traits. In agreement with similar efforts using different models, we show that the expected degree to which two groups differ on a neutral quantitative trait is not strongly affected by the number of genetic loci that influence the trait: neutral trait differences are expected to have a magnitude comparable to the genetic differences at a single neutral locus. We discuss this result with respect to population differences in disease phenotypes, arguing that although neutral genetic differences between populations can contribute to specific differences between populations in health outcomes, systematic patterns of difference that run in the same direction for many genetically independent health conditions are unlikely to be explained by neutral genetic differentiation.
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