ArticlePloS one2016
A dedicated fungal culture medium is useful in the diagnosis of fungemia: a retrospective cross-sectional study.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed, 16 citations in OpenAlex.
- Evaluation of Different Blood Culture Bottles for the Diagnosis of Bloodstream Infections in Patients with HIV.Infectious diseases and therapy · 2023Article
- A Dedicated Mycosis Flask Increases the Likelihood of Identifying Candidemia Sepsis.Journal of fungi (Basel, Switzerland) · 2023Article
- Evaluation of an Antifungal Stewardship Initiative Targeting Micafungin at an Academic Medical Center.Antibiotics (Basel, Switzerland) · 2023Article
- Epidemiological Trends of Candidemia and the Impact of Adherence to the Candidemia Guideline: Six-Year Single-Center Experience.Journal of fungi (Basel, Switzerland) · 2021Article
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6 authors at 1 institution in 1 country.
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Abstract
backgroundMortality for candidemia ranges from 15% to 35%. Current guidelines recommend inoculating blood into three aerobic and three anaerobic blood culture bottles when candidemia is suspected, without mention of a fungal blood culture bottle.
objectiveTo determine the value of the BACTEC Myco/F Lytic blood culture media in the diagnosis of fungemia.
methodsA two-year retrospective cross-sectional study was performed for patients who had fungemia with submitted BACTEC Plus Aerobic/F (Aer), BACTEC Plus Anaerobic/F (Anaer) or Myco/F Lytic (Myco) blood culture bottles.
resultsThe detection rate of fungemia was 77.4% in 93 patients with contemporaneously submitted blood culture bottles when limited to only Aer/Anaer culture results. The detection rate improved significantly with the addition of the Myco culture bottle results (p<0.0001). A logistic regression model showed that Myco culture bottle submissions were less useful for patients with appropriate anti-fungal therapy administered within 48 hours [OR = 0.18, 95% CI = (0.06, 0.49), p = 0.001] and those with fungal growth detected within 48 hours [OR = 0.33, 95% CI = (0.12, 0.89), p = 0.001]. Among a subset of patients with concordant blood culture results, those with Myco culture bottles submission allowed earlier fungal detection and speciation by at least one day in 27.5% and 25.0% of the cases respectively.
conclusionOur study highlights the importance of a dedicated fungal blood culture when fungemia is clinically suspected. Nearly a quarter of fungemias may be missed if a fungal blood culture is not performed.
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