ArticlePloS one2016
Choroidal Structure in Children with Anisohypermetropic Amblyopia Determined by Binarization of Optical Coherence Tomographic Images.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Analysis of retina, choroid, and microvascular structures in amblyopic patients using OCT and OCTA.BMC ophthalmology · 2026Article
- Choroidal vascular characteristics in anisometropic amblyopia: a comparative analysis.BMC ophthalmology · 2025Article
- Choroidal Morphology and Photoreceptor Activity Are Related and Affected by Myopia Development.Investigative ophthalmology & visual science · 2024Article
- Choroidal vasculature act as predictive biomarkers of long-term ocular elongation in myopic children treated with orthokeratology: a prospective cohort study.Eye and vision (London, England) · 2023Article
- Choroidal thickness and vascular microstructure parameters in Chinese school-age children with highFrontiers in pediatrics · 2023Article
- Ocular blood flow evaluation by laser speckle flowgraphy in pediatric patients with anisometropia.Frontiers in public health · 2023Article
- Evaluation of Choroidal Vascular Structure in Hyperopic Anisometropic Amblyopia.Beyoglu eye journal · 2023Article
- Effect of foveal morphology on visual acuity in 4-6-year-old children with retinopathy of prematurity: a J-CREST study.Scientific reports · 2022Article
- How does anisometropia affect the choroidal vascularity index?Indian journal of ophthalmology · 2022Article
- Assessment of choroidal vascularity and choriocapillaris blood perfusion in Chinese preschool-age anisometropic hyperopic amblyopia children.Frontiers in pediatrics · 2022Article
- Differences in Retinal and Choroidal Vasculature and Perfusion Related to Axial Length in Pediatric Anisomyopes.Investigative ophthalmology & visual science · 2021Article
- Choroidal and Macular Thickness in Eyes with Amblyopia.Beyoglu eye journal · 2021Article
- Choroidal vessel density in unilateral hyperopic amblyopia using en-face optical coherence tomography.BMC ophthalmology · 2020Article
- Effect of optical correction on choroidal structure in children with anisohypermetropic amblyopia.PloS one · 2020Article
- Abnormal Outer Choroidal Vasculature in Amblyopia.Journal of ophthalmology · 2019Article
- Effect of amblyopia treatment on choroidal thickness in hypermetropic anisometropic amblyopia using swept-source optical coherence tomography.BMC ophthalmology · 2018Observational
- Semi-automated software to measure luminal and stromal areas of choroid in optical coherence tomographic images.Japanese journal of ophthalmology · 2018Article
- Changes in choroidal blood flow and choroidal thickness after treatment in two cases of pediatric anisohypermetropic amblyopia.American journal of ophthalmology case reports · 2017Article
- Effect of optical correction on subfoveal choroidal thickness in children with anisohypermetropic amblyopia.PloS one · 2017Observational
- CAN Optical Coherence Tomography redefine amblyopia?Romanian journal of ophthalmologyReview
Corrections and comments
- Erratum issued
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo compare the choroidal structure of the subfoveal area in the eyes of children with anisohypermetropic amblyopia to that of the fellow eyes and to age-matched controls using a binarization method of the images obtained by enhanced depth imaging optical coherence tomography (EDI-OCT).
methodsThis study was performed at Nara Medical University Hospital, Tokushima University Hospital, and Kagoshima University Hospital, Japan. Forty amblyopic eyes with anisohypermetropic amblyopia and their fellow eyes (5.9 ± 2.1 years, mean ± standard deviation), and 103 age-matched controls (6.7 ± 2.4 years) were studied. The control eyes were divided into myopic, emmetropic, and hyperopic eyes. The total choroidal area, luminal area and stromal area of the subfoveal choroid were measured by the binarization method. The luminal/stromal ratio and the axial length of the amblyopic eyes were compared to that of the control eyes.
resultsThe total choroidal area in the amblyopic eyes was significantly larger than that of the fellow eyes (P = 0.005). The luminal/stromal ratio was significantly larger in the amblyopic eyes than that of the fellow eyes (P<0.001) and the control hyperopic eyes (P<0.001). There was a significant negative correlation between the luminal/stromal ratio and the axial length in the control eyes (r = -0.30, P = 0.001), but no significant correlation was found in the amblyopic eyes.
conclusionsThe choroidal structure of the amblyopic eyes was different from that of the fellow and the control hyperopic eyes. The choroidal changes are related to amblyopia.
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