ArticlePloS one2016
Associations of Prolonged QTc in Sickle Cell Disease.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 29 citations in OpenAlex.
- Sickle cell related cardiomyopathy and cardiovascular autonomic dysfunction.Frontiers in cardiovascular medicine · 2026Review
- Is anaemia associated with QTc prolongation? A retrospective cross-sectional analysis from a rural population-based cohort.BMJ open · 2025Observational
- Prevalence of Electrocardiographic Changes and Risk Factors for QTc Prolongation Among Steady State Sickle Cell Disease Patients: Cooperative Study of Sickle Cell Disease.Oman medical journal · 2025Article
- Electrocardiographic findings in patients with sickle cell disease: A protocol for systematic review and meta-analysis.Health science reports · 2024Article
- Clinical and Laboratory Correlates of QTc Duration in Adult and Pediatric Sickle Cell Disease.American journal of medicine open · 2023Article
- Blood pressure and electrocardiographic profile of children with sickle cell anaemia in steady-state and vaso-occlusive crisis.Ghana medical journal · 2023Article
- Ventricular arrhythmias in sickle cell anemia.Blood · 2023Article
- The Cardiopulmonary Complications of Sickle Cell Disease.Hematology/oncology clinics of North America · 2022Review
- Protocol-based cardiotoxicity monitoring in hydroxychloroquine medicated COVID-19 pediatric patients.Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology · 2022Article
- Cardiac pathophysiology in sickle cell disease.Journal of thrombosis and thrombolysis · 2021Review
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- Sickle cell disease-associated arrhythmias and in-hospital outcomes: Insights from the National Inpatient Sample.Journal of arrhythmia · 2020Article
- Reversal of a rheologic cardiomyopathy following hematopoietic stem cell transplantation for sickle cell disease.Blood advances · 2019Article
- Association of circulating transcriptomic profiles with mortality in sickle cell disease.Blood · 2017Article
- Impact of relative systemic hypertension on the heart in sickle cell anaemia.Indian heart journalArticle
Corrections and comments
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Authors and funding
20 authors at 5 institutions in 1 country.
Funding
Abstract
Sudden death is a leading cause of mortality in sickle cell disease, implicating ventricular tachyarrhythmias. Prolonged QTc on an electrocardiogram (ECG), commonly seen with myocardial ischemia, is a known risk for polymorphic ventricular tachycardia (VT). We hypothesized that prolonged QTc is associated with mortality in sickle cell disease. ECG were analyzed from a cohort of 224 sickle patients (University of Illinois at Chicago, UIC) along with available laboratory, and echocardiographic findings, and from another cohort of 38 patients (University of Chicago, UC) for which cardiac MRI and free heme values were also measured. In the UIC cohort, QTc was potentially related to mortality with a hazard ratio (HR) of 1.22 per 10ms, (P = 0.015), and a HR = 3.19 (P = 0.045) for a QTc>480ms. In multivariate analyses, QTc remained significantly associated with survival after adjusting for inpatient ECG status (HR 1.26 per 10ms interval, P = 0.010) and genotype status [HR 1.21 per 10ms interval, P = 0.037). QTc trended toward association with mortality after adjusting for both LDH and hydroxyurea use (HR 1.21 per 10ms interval, P = 0.062) but was not significant after adjusting for TRV. In univariate analyses, QTc was related to markers of hemolysis including AST (P = 0.031), hemoglobin (P = 0.014), TR velocity (P = 0.036), higher in inpatients (P<0.001) and those with an SS compared to SC genotype (P<0.001) in the UIC cohort as well as to free heme in the UC cohort (P = 0.002). These findings support a relationship of prolonged QTc with hemolysis and potentially mortality in sickle cell disease.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.