ArticlePloS one2016
Urodynamic Investigation: A Valid Tool to Define Normal Lower Urinary Tract Function?
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 40 citations in OpenAlex.
- Trial
- Detrusor Overactivity and Urodynamics.Neurourology and urodynamics · 2026Review
- Artifacts in Urodynamic Studies: A Narrative Review.Neurourology and urodynamics · 2025Review
- Continuous Monitoring of Bladder Dysfunction in People With Multiple Sclerosis: Wearables for the Bladder.Annals of clinical and translational neurology · 2025Article
- Expanded Physiological Testing of the Lower Urinary Tract in Asymptomatic Women and Those With Urgency Urinary Incontinence: Findings From the LURN-Organ Study.Neurourology and urodynamics · 2025Observational
- New Imaging Techniques on the Horizon to Study Overactive and Neurogenic Bladder.Current bladder dysfunction reports · 2025Review
- Ultrasound Urodynamics: A Review of Ultrasound Imaging Techniques for Enhanced Bladder Functional Diagnostics.Current bladder dysfunction reports · 2024Review
- Neurogenic Bladder in Dogs, Cats and Humans: A Comparative Review of Neurological Diseases.Animals : an open access journal from MDPI · 2022Review
- Targeting bladder function with network-specific epidural stimulation after chronic spinal cord injury.Scientific reports · 2022Article
- Influence of visual and auditory cues about bladder volume on real-time filling sensation in healthy volunteers.American journal of clinical and experimental urology · 2022Article
- Artifacts and abnormal findings may limit the use of asymptomatic volunteers as controls for studies of multichannel urodynamics.Minerva urology and nephrology · 2021Article
- Is Nocturia Associated With Detrusor Underactivity?Female pelvic medicine & reconstructive surgery · 2021Article
- Aging Changes in Bladder Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels Are Associated With Increasing Heterogeneity of Adrenergic/Mucosal Influence on Detrusor Control in the Mouse.The journals of gerontology. Series A, Biological sciences and medical sciences · 2021Article
- Sexual dimorphism of detrusor function demonstrated by urodynamic studies in rhesus macaques.Scientific reports · 2020Article
- Best practices for cystometric evaluation of lower urinary tract function in muriform rodents.Neurourology and urodynamics · 2020Article
- Comparative-fill urodynamics in individuals with and without detrusor overactivity supports a conceptual model for dynamic elasticity regulation.Neurourology and urodynamics · 2020Article
- Dilemmas in Management of the Geriatric Bladder.Current bladder dysfunction reports · 2019Article
- Validation of a real-time bladder sensation meter during oral hydration in healthy adults: Repeatability and effects of fill rate and ultrasound probe pressure.Lower urinary tract symptoms · 2019Article
- Wireless intravesical device for real-time bladder pressure measurement: Study of consecutive voiding in awake minipigs.PloS one · 2019Article
- [Urodynamic studies prior to urinary incontinence surgery : What is useful?]Der Urologe. Ausg. A · 2017Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo evaluate whether urodynamic investigation (UDI), the gold standard to assess refractory lower urinary tract symptoms (LUTS), is appropriate to select healthy volunteers with apparent normal lower urinary tract function as control subjects for comparative studies. SUBJECTS AND
methods42 healthy subjects (22 women, mean age 32±10 years; 20 men, mean age 37±12 years) without LUTS were included into this prospective single-centre cohort study. All subjects recorded a 3-day bladder diary, completed validated questionnaires regarding LUTS, and underwent neuro-urological assessment as well as free uroflowmetry. Same session repeat UDI was performed according to "Good Urodynamic Practice" recommended by the International Continence Society, but using an air-charged instead of a water-filled catheter, and evaluated by a blinded investigator.
resultsAll 3-day bladder diaries, LUTS questionnaires, neuro-urological assessments and free uroflowmetries were within normal limits. Overall (either during the first or second UDI), same session repeat UDI revealed pathological findings in 71% (30/42): Detrusor overactivity was detected in 14% (3/22) and 30% (6/20), post void residual >100mL in 14% (3/22) and 25% (5/20), bladder outlet obstruction in 9% (2/22) and 20% (4/20) and detrusor sphincter dyssynergia in 77% (17/22) and 65% (13/20) of our women and men, respectively. Repeatability of detrusor overactivity (κ = 0.78, 95% CI: 0.54-1.02) and detrusor sphincter dyssynergia (κ = 0.77, 95% CI: 0.55-0.98) showed substantial agreement between both UDIs. All other assessed urodynamic parameters had wide 95% limits of agreement for differences in the parameters indicating poor repeatability.
conclusionsMore than 70% of our healthy subjects showed pathological urodynamic findings. Although UDI is the gold standard to assess refractory LUTS, it seems not to be applicable in healthy subjects to define normal lower urinary tract function. Therefore, we do not recommend using UDI to select healthy control subjects.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.