Evidence map›Paper›PMID 27736784›Full record

ArticleInfection and immunity2016

Antibodies Targeting Hsa and PadA Prevent Platelet Aggregation and Protect Rats against Experimental Endocarditis Induced by Streptococcus gordonii.

Stefano Mancini, Carmen Menzi, Frank Oechslin, Philippe Moreillon, José Manuel Entenza

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Infection and immunity, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

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  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Stefano ManciniDepartment of Fundamental Microbiology, University of Lausanne, Lausanne, Switzerland.
Carmen MenziDepartment of Fundamental Microbiology, University of Lausanne, Lausanne, Switzerland.
Frank OechslinDepartment of Fundamental Microbiology, University of Lausanne, Lausanne, Switzerland.
Philippe MoreillonDepartment of Fundamental Microbiology, University of Lausanne, Lausanne, Switzerland.
José Manuel EntenzaDepartment of Fundamental Microbiology, University of Lausanne, Lausanne, Switzerland jose.entenza@unil.ch.
University of Lausanne · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Streptococcus gordonii and related species of oral viridans group streptococci (VGS) are common etiological agents of infective endocarditis (IE). We explored vaccination as a strategy to prevent VGS-IE, using a novel antigen-presenting system based on non-genetically modified Lactococcus lactis displaying vaccinogens on its surface. Hsa and PadA are surface-located S. gordonii proteins implicated in platelet adhesion and aggregation, which are key steps in the pathogenesis of IE. This function makes them ideal targets for vaccination against VGS-IE. In the present study, we report the use of nonliving L. lactis displaying at its surface the N-terminal region of Hsa or PadA by means of the cell wall binding domain of Lactobacillus casei A2 phage lysine LysA2 (Hsa-LysA2 and PadA-LysA2, respectively) and investigation of their ability to elicit antibodies in rats and to protect them from S. gordonii experimental IE. Immunized and control animals with catheter-induced sterile aortic valve vegetations were inoculated with 10

Indexed as

Adhesins, BacterialAnimalsAntibodies, BacterialBacterial VaccinesCarrier ProteinsEndocarditis, BacterialFemaleGene Expression Regulation, BacterialHemagglutinins, ViralLactobacillus leichmanniiPlatelet AggregationRatsStreptococcal InfectionsStreptococcus gordoniiAdhesins, BacterialAntibodies, BacterialBacterial VaccinesCarrier ProteinsHemagglutinins, Viralhsa protein, Streptococcus gordonii

Identifiers

PMID27736784
PMCPMC5116732
OpenAlexW2530275193

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.