ArticleInfection and immunity2016
Protein Malnutrition Impairs Intestinal Epithelial Cell Turnover, a Potential Mechanism of Increased Cryptosporidiosis in a Murine Model.
Article in Infection and immunity, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed, 53 citations in OpenAlex.
- Bidirectional Relationship Between Gastroparesis and Malnutrition.Digestive diseases and sciences · 2025Article
- Organoid-basedMicrobiology spectrum · 2025Article
- Enhancing Resistance toNutrients · 2025Article
- Cryptosporidium modifies intestinal microvilli through an exported virulence factor.Cell host & microbe · 2025Article
- Review
- Impact of Rotaviral Diarrhea on Child Growth in Sub-Saharan Africa and South Asia in the Global Enteric Multicenter Study.The American journal of tropical medicine and hygiene · 2024Article
- Fecal microbiota impacts development of Cryptosporidium parvum in the mouse.Scientific reports · 2024Article
- C3a/C3aR Affects the Propagation ofAnimals : an open access journal from MDPI · 2023Article
- Apoptotic changes in the intestinal epithelium ofJournal of parasitic diseases : official organ of the Indian Society for Parasitology · 2022Article
- Article
- Single-cell profiling of environmental enteropathy reveals signatures of epithelial remodeling and immune activation.Science translational medicine · 2022Article
- Article
- Modeling Enteropathy or Diarrhea with the Top Bacterial and Protozoal Pathogens: Differential Determinants of Outcomes.ACS infectious diseases · 2021Review
- Article
- Reversal of Pathogen-Induced Barrier Defects in Intestinal Epithelial Cells by Contra-pathogenicity Agents.Digestive diseases and sciences · 2021Article
- Phosphoglycerate kinase: structural aspects and functions, with special emphasis on the enzyme from Kinetoplastea.Open biology · 2020Review
- Epithelium intrinsic vitamin A signaling co-ordinates pathogen clearance in the gut via IL-18.PLoS pathogens · 2020Article
- Malnutrition Decreases Antibody Secreting Cell Numbers Induced by an Oral Attenuated Human Rotavirus Vaccine in a Human Infant Fecal Microbiota Transplanted Gnotobiotic Pig Model.Frontiers in immunology · 2020Article
- Deprivation of dietary fiber enhances susceptibility of mice to cryptosporidiosis.PLoS neglected tropical diseases · 2019Article
- Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
Malnutrition and cryptosporidiosis form a vicious cycle and lead to acute and long-term growth impairment in children from developing countries. Insights into mechanisms underlying the vicious cycle will help to design rational therapies to mitigate this infection. We tested the effect of short-term protein malnutrition on Cryptosporidium parvum infection in a murine model by examining stool shedding, tissue burden, and histologic change and explored the mechanism underlying the interaction between malnutrition and cryptosporidiosis through immunostaining and immunoblotting. Protein malnutrition increased stool shedding and the number of intestine-associated C. parvum organisms, accompanied by significant suppression of C. parvum-induced caspase 3 activity and expression of PCNA and Ki67, but activation of the Akt survival pathway in intestinal epithelial cells. We find that even very brief periods of protein malnutrition may enhance (or intensify) cryptosporidiosis by suppressing C. parvum-induced cell turnover and caspase-dependent apoptosis of intestinal epithelial cells. This implicates a potential strategy to attenuate C. parvum's effects by modulating apoptosis and promoting regeneration in the intestinal epithelium.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.