Evidence map›Paper›PMID 27736777›Full record

ArticleInfection and immunity2016

Genome-Wide Association Study of Cell-Mediated Response in Dogs Naturally Infected by Leishmania infantum.

Luís F S Batista, Yuri T Utsunomiya, Thaís B F Silva, Raíssa A Dias, Thaise Y Tomokane, Acácio D Pacheco, Vânia L R da Matta, Fernando T Silveira, Mary Marcondes, Cáris M Nunes and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in Infection and immunity, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. Pooled it
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  5. Article
  6. Is the Prevalence ofAnimals : an open access journal from MDPI · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Luís F S BatistaDepartamento de Patologia Veterinária, Faculdade de Medicina Veterinária e Zootecnia, Universidade de São Paulo, São Paulo, Brazil.
Yuri T UtsunomiyaUniversidade Estadual Paulista, Departamento de Medicina Veterinária Preventiva e Reprodução Animal, Faculdade de Ciências Agrárias e Veterinárias, Jaboticabal, São Paulo, Brazil.
Thaís B F SilvaLaboratório de Patologia de Doenças Infecciosas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.
Raíssa A DiasLaboratório de Patologia de Doenças Infecciosas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.
Thaise Y TomokaneLaboratório de Patologia de Doenças Infecciosas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.ORCID http://orcid.org/0000-0002-1431-6829
Acácio D PachecoUniversidade Estadual Paulista, Departamento de Clínica, Cirurgia e Reprodução Animal, Faculdade de Medicina Veterinária, Araçatuba, São Paulo, Brazil.
Vânia L R da MattaLaboratório de Patologia de Doenças Infecciosas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.
Fernando T SilveiraLaboratório de Patologia de Doenças Infecciosas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.
Mary MarcondesUniversidade Estadual Paulista, Departamento de Clínica, Cirurgia e Reprodução Animal, Faculdade de Medicina Veterinária, Araçatuba, São Paulo, Brazil.
Cáris M NunesUniversidade Estadual Paulista, Departmento de Saúde Animal e Produção, Faculdade de Medicina Veterinária, Araçatuba, São Paulo, Brazil.
Márcia D LaurentiLaboratório de Patologia de Doenças Infecciosas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil mdlauren@usp.br.
Universidade de São Paulo · BRUniversidade Estadual Paulista (Unesp) · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A genome-wide association study (GWAS) could unravel the complexity of the cell-mediated immunity (CMI) to canine leishmaniasis (CanL). Therefore, we scanned 110,165 single-nucleotide polymorphisms (SNPs), aiming to identify chromosomal regions associated with the leishmanin skin test (LST), lymphocyte proliferation assay (LPA), and cytokine responses to further understand the role played by CMI in the outcome of natural Leishmania infantum infection in 189 dogs. Based on LST and LPA, four CMI profiles were identified (LST

Indexed as

Genome-Wide Association StudyLeishmania infantumAnimalsCell ProliferationCytokinesDog DiseasesDogsFemaleGene Expression RegulationImmunity, CellularLeishmaniasis, VisceralLymphocytesMaleSkin TestsCytokines

Identifiers

PMID27736777
PMCPMC5116739
OpenAlexW2531905906

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.