Evidence map›Paper›PMID 27736748›Full record

ReviewDisease models & mechanisms2016

Rat models of spinal cord injury: from pathology to potential therapies.

Jacob Kjell, Lars Olson

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Disease models & mechanisms, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 206 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
206citing papers in PubMed, 9 pooled it
18.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

206 citing papers in PubMed, 9 syntheses or guidelines pooled it, 399 citations in OpenAlex.

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  9. Histological Findings After Aortic Cross-Clamping in Preclinical Animal Models.Journal of neuropathology and experimental neurology · 2021
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146 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

Jacob KjellDepartment of Physiological Genomics, Ludwig-Maximilians-Universität München, Munich 80336, Germany jacob.kjell@med.uni-muenchen.de lars.olson@ki.se.ORCID 0000-0002-8335-0780
Lars OlsonDepartment of Neuroscience, Karolinska Institutet, Stockholm 171 77, Sweden jacob.kjell@med.uni-muenchen.de lars.olson@ki.se.ORCID 0000-0001-7378-7420
Karolinska Institutet · SELudwig-Maximilians-Universität München · DE

Funding

European Research Council 322744
6 · The paper itself

Abstract

A long-standing goal of spinal cord injury research is to develop effective spinal cord repair strategies for the clinic. Rat models of spinal cord injury provide an important mammalian model in which to evaluate treatment strategies and to understand the pathological basis of spinal cord injuries. These models have facilitated the development of robust tests for assessing the recovery of locomotor and sensory functions. Rat models have also allowed us to understand how neuronal circuitry changes following spinal cord injury and how recovery could be promoted by enhancing spontaneous regenerative mechanisms and by counteracting intrinsic inhibitory factors. Rat studies have also revealed possible routes to rescuing circuitry and cells in the acute stage of injury. Spatiotemporal and functional studies in these models highlight the therapeutic potential of manipulating inflammation, scarring and myelination. In addition, potential replacement therapies for spinal cord injury, including grafts and bridges, stem primarily from rat studies. Here, we discuss advantages and disadvantages of rat experimental spinal cord injury models and summarize knowledge gained from these models. We also discuss how an emerging understanding of different forms of injury, their pathology and degree of recovery has inspired numerous treatment strategies, some of which have led to clinical trials.

Indexed as

AnimalsClinical Trials as TopicDisease Models, AnimalHumansInflammationNerve RegenerationRatsRecovery of FunctionSpinal Cord InjuriesClinical trialsRatRegenerationRepairSpinal cord injury

Identifiers

PMID27736748
PMCPMC5087825
OpenAlexW2528095620

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.