ArticleNature protocols2016
Fabrication and utility of a transparent graphene neural electrode array for electrophysiology, in vivo imaging, and optogenetics.
Article in Nature protocols, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed.
- Solution-processed aqueous-insensitive transparent conductors for bio-optoelectronics.Nature communications · 2026Article
- Multimodal Optical Imaging and Modulation with Simultaneous Electrophysiology Through Smart Dura in Non-Human Primates.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Dynamic neuronal ensembles encode burst-suppression revealed by cortex-wide optical-electrical interfaces.Nature communications · 2026Article
- Simultaneous In Vivo Electrophysiology, Two-Photon Imaging, and Optogenetics for Probing Neurovascular Coupling.Methods and protocols · 2026Article
- Single-Die-Level MEMS Post-Processing for Prototyping CMOS-Based Neural Probes Combined with Optical Fibers for Optogenetic Neuromodulation.Micromachines · 2026Article
- Biological performance evaluation of graphene nanoplatelets for intracranial direct current stimulation.Frontiers in neuroscience · 2026Article
- Multimodal Optical Imaging and Modulation through Smart Dura in Non-Human Primates.bioRxiv : the preprint server for biology · 2025Article
- Transparent, metal-free PEDOT:PSS neural interfaces for simultaneous recording of low-noise electrophysiology and artifact-free two-photon imaging.Nature communications · 2025Article
- A soft multimodal optoelectronic array interface for multiparametric mapping of heart function in vivo.Science advances · 2025Article
- StressFit: a hybrid wearable physicochemical sensor suite for simultaneously measuring electromyogram and sweat cortisol.Scientific reports · 2024Article
- Recent Advancements in Graphene-Based Implantable Electrodes for Neural Recording/Stimulation.Sensors (Basel, Switzerland) · 2023Review
- Emerging trends in the development of flexible optrode arrays for electrophysiology.APL bioengineering · 2023Review
- Transparent Electronics for Wearable Electronics Application.Chemical reviews · 2023Review
- Localised surface plasmon resonance inducing cooperative Jahn-Teller effect for crystal phase-change in a nanocrystal.Nature communications · 2023Article
- Transparent and Stretchable Au─Ag Nanowire Recording Microelectrode Arrays.Advanced materials technologies · 2023Article
- Transparent neural interfaces: challenges and solutions of microengineered multimodal implants designed to measure intact neuronal populations using high-resolution electrophysiology and microscopy simultaneously.Microsystems & nanoengineering · 2023Review
- Novel Nanotechnology-Driven Prototypes for AI-Enriched Implanted Prosthetics Following Organ Failure.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Graphene-based cardiac sensors and actuators.Frontiers in bioengineering and biotechnology · 2023Review
- Advances in electrode interface materials and modification technologies for brain-computer interfaces.Biomaterials translational · 2023Review
- In Vivo Penetrating Microelectrodes for Brain Electrophysiology.Sensors (Basel, Switzerland) · 2022Review
Corrections and comments
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Authors and funding
19 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Transparent graphene-based neural electrode arrays provide unique opportunities for simultaneous investigation of electrophysiology, various neural imaging modalities, and optogenetics. Graphene electrodes have previously demonstrated greater broad-wavelength transmittance (∼90%) than other transparent materials such as indium tin oxide (∼80%) and ultrathin metals (∼60%). This protocol describes how to fabricate and implant a graphene-based microelectrocorticography (μECoG) electrode array and subsequently use this alongside electrophysiology, fluorescence microscopy, optical coherence tomography (OCT), and optogenetics. Further applications, such as transparent penetrating electrode arrays, multi-electrode electroretinography, and electromyography, are also viable with this technology. The procedures described herein, from the material characterization methods to the optogenetic experiments, can be completed within 3-4 weeks by an experienced graduate student. These protocols should help to expand the boundaries of neurophysiological experimentation, enabling analytical methods that were previously unachievable using opaque metal-based electrode arrays.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.