ArticleSensors (Basel, Switzerland)2016
Mid-Infrared Photoacoustic Detection of Glucose in Human Skin: Towards Non-Invasive Diagnostics.
Article in Sensors (Basel, Switzerland), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
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Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Photoacoustic Resonators for Non-Invasive Blood Glucose Detection Through Photoacoustic Spectroscopy: A Systematic Review.Sensors (Basel, Switzerland) · 2024Pooled it
- Photoacoustic Noninvasive Blood Glucose Monitoring: A Review of Systems and Strategies for Robust Glucose Concentration Estimation, with Perspectives on Miniaturization and Wearability.Sensors (Basel, Switzerland) · 2026Review
- Transducer Systems Integrated into Organ-on-a-Chip Devices: From Detection to Fabrication.Small (Weinheim an der Bergstrasse, Germany) · 2026Review
- A Linear and High-Sensitivity Microwave Biosensor on a FR-4 Substrate for Aqueous Glucose Monitoring Using a Concentric Square-Shaped Split-Ring Resonator.Sensors (Basel, Switzerland) · 2025Article
- Noninvasive Analysis of Biological Components Using Simplified Mid-Infrared Photothermal Deflection Spectroscopy.Sensors (Basel, Switzerland) · 2025Article
- Analysis of glucose concentrations in blood solutions using FTIR and Raman spectroscopy methods.Biomedical optics express · 2025Article
- Effects of Skin Blood Flow Fluctuations on Non-Invasive Glucose Measurement and a Feasible Blood Flow Control Method.Sensors (Basel, Switzerland) · 2025Article
- ppb-Level SOSensors (Basel, Switzerland) · 2024Article
- Non-invasive glucose extraction by a single polarization rotator system in patients with diabetes.Biomedical optics express · 2024Article
- Noninvasive Glucose Sensing In Vivo.Sensors (Basel, Switzerland) · 2023Review
- Niche preclinical and clinical applications of photoacoustic imaging with endogenous contrast.Photoacoustics · 2023Review
- Progress and Perspectives of Mid-Infrared Photoacoustic Spectroscopy for Non-Invasive Glucose Detection.Biosensors · 2023Review
- Mid-infrared photoacoustic spectroscopy based on ultrasound detection for blood component analysis.Biomedical optics express · 2023Article
- The sound of blood: photoacoustic imaging in blood analysis.Medicine in novel technology and devices · 2023Article
- Dual quantum cascade lasers for noninvasive glucose detection using photoacoustic spectroscopy.Scientific reports · 2023Article
- Glucose diagnosis system combining machine learning and NIR photoacoustic multispectral using a low power CW laser.Biomedical optics express · 2023Article
- Selection of Noninvasive Features in Wrist-Based Wearable Sensors to Predict Blood Glucose Concentrations Using Machine Learning Algorithms.Sensors (Basel, Switzerland) · 2022Article
- A Single Wavelength Mid-Infrared Photoacoustic Spectroscopy for Noninvasive Glucose Detection Using Machine Learning.Biosensors · 2022Article
- Glucose Determination by a Single 1535 nm Pulsed Photoacoustic Technique: A Multiple Calibration for the External Factors.Journal of healthcare engineering · 2022Article
- Nanozyme-based colorimetric biosensor with a systemic quantification algorithm for noninvasive glucose monitoring.Theranostics · 2022Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Diabetes mellitus is a widespread metabolic disease without cure. Great efforts are being made to develop a non-invasive monitoring of the blood glucose level. Various attempts have been made, including a number of non-optical approaches as well as optical techniques involving visible, near- and mid-infrared light. However, no true breakthrough has been achieved so far, i.e., there is no fully non-invasive monitoring device available. Here we present a new study based on mid-infrared spectroscopy and photoacoustic detection. We employ two setups, one with a fiber-coupled photoacoustic (PA) cell and a tunable quantum cascade laser (QCL), and a second setup with two QCLs at different wavelengths combined with PA detection. In both cases, the PA cells are in direct skin contact. The performance is tested with an oral glucose tolerance test. While the first setup often gives reasonable qualitative agreement with ordinary invasive blood glucose measurements, the dual-wavelength approach yields a considerably improved stability and an uncertainty of only ±30 mg/dL of the blood glucose concentration level at a confidence level of 90%. This result is achieved without advanced data treatment such as principal component analysis involving extended wavelength ranges.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.