Evidence map›Paper›PMID 27735866›Full record

ArticleBrain sciences2016

Vocal Tremor: Novel Therapeutic Target for Deep Brain Stimulation.

Vinod K Ravikumar, Allen L Ho, Jonathon J Parker, Elizabeth Erickson-DiRenzo, Casey H Halpern

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 13 citations in OpenAlex.

  1. Sodium Oxybate in Alcohol-Responsive Essential Tremor of Voice: An Open-Label Phase II Study.Movement disorders : official journal of the Movement Disorder Society · 2023
    Trial
  2. Treatment of Neurogenic Voice Disorders.World journal of otorhinolaryngology - head and neck surgery · 2025
    Review
  3. Article
  4. Review
  5. Isolated Voice Tremor: A Clinical Variant of Essential Tremor or a Distinct Clinical Phenotype?Tremor and other hyperkinetic movements (New York, N.Y.) · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Vinod K RavikumarDepartment of Neurosurgery, Stanford University, 300 Pasteur Dr., Edwards Bldg. R-293, Stanford, CA 94305, USA. vinod.rr@gmail.com.
Allen L HoDepartment of Neurosurgery, Stanford University, 300 Pasteur Dr., Edwards Bldg. R-293, Stanford, CA 94305, USA. aho5@stanford.edu.
Jonathon J ParkerDepartment of Neurosurgery, Stanford University, 300 Pasteur Dr., Edwards Bldg. R-293, Stanford, CA 94305, USA. parkerjo@stanford.edu.
Elizabeth Erickson-DiRenzoDepartment of Neurosurgery, Stanford University, 300 Pasteur Dr., Edwards Bldg. R-293, Stanford, CA 94305, USA. edirenzo@ohns.stanford.edu.
Casey H HalpernDepartment of Neurosurgery, Stanford University, 300 Pasteur Dr., Edwards Bldg. R-293, Stanford, CA 94305, USA. chalpern@stanford.edu.
Stanford University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tremulous voice is characteristically associated with essential tremor, and is referred to as essential vocal tremor (EVT). Current estimates suggest that up to 40% of individuals diagnosed with essential tremor also present with EVT, which is associated with an impaired quality of life. Traditional EVT treatments have demonstrated limited success in long-term management of symptoms. However, voice tremor has been noted to decrease in patients receiving deep brain stimulation (DBS) with the targeting of thalamic nuclei. In this study, we describe our multidisciplinary procedure for awake, frameless DBS with optimal stimulation targets as well as acoustic analysis and laryngoscopic assessment to quantify tremor reduction. Finally, we investigate the most recent clinical evidence regarding the procedure.

Indexed as

acoustic analysisawake DBSdeep brain stimulationdysphoniaessential tremoressential vocal tremorEVTlaryngoscopymicroelectrode recordingtremulous voiceventral intermediate nucleusVIMvoice

Identifiers

PMID27735866
PMCPMC5187562
OpenAlexW2530372626

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.