ArticleSensors (Basel, Switzerland)2016
An Infrared Absorbance Sensor for the Detection of Melanoma in Skin Biopsies.
Article in Sensors (Basel, Switzerland), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 16 citations in OpenAlex.
- Electromagnetic Sensing Techniques for Monitoring Atopic Dermatitis-Current Practices and Possible Advancements: A Review.Sensors (Basel, Switzerland) · 2023Review
- Optical Technologies for the Improvement of Skin Cancer Diagnosis: A Review.Sensors (Basel, Switzerland) · 2021Review
- Performance Assessment of Low-Cost Thermal Cameras for Medical Applications.Sensors (Basel, Switzerland) · 2020Article
- Skin cancer detection using non-invasive techniques.RSC advances · 2018Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
An infrared (IR) absorbance sensor has been designed, realized and tested with the aim of detecting malignant melanomas in human skin biopsies. The sensor has been designed to obtain fast measurements (80 s) of a biopsy using a small light spot (0.5 mm in diameter, typically five to 10 times smaller than the biopsy size) to investigate different biopsy areas. The sensor has been equipped with a monochromator to record the whole IR spectrum in the 3330-3570 nm wavelength range (where methylene and methyl stretching vibrations occur) for a qualitative spectral investigation. From the collected spectra, the CH₂ stretch ratio values (ratio of the absorption intensities of the symmetric to asymmetric CH₂ stretching peaks) are determined and studied as a cancer indicator. Melanoma areas exhibit different spectral shapes and significantly higher CH₂ stretch ratios when compared to healthy skin. The results of the infrared investigation are compared with standard histology. This study shows that the IR sensor is a promising supportive tool to improve the diagnosis of melanoma during histopathological analysis, decreasing the risk of misdiagnosis.
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Registered trials
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