ArticleScientific reports2016
Molecular evolution of a widely-adopted taxonomic marker (COI) across the animal tree of life.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers.
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Who cites it
69 citing papers in PubMed, 215 citations in OpenAlex.
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- Spatio-temporal metabarcoding surveys in ports reveal homogenised communities of non-indigenous species with high genetic diversity and connectivity.Scientific reports · 2026Article
- Comparative Multi-Marker Environmental DNA Metabarcoding of Marine Metazoan Communities: Water vs. Sediment.Molecular ecology resources · 2026Article
- High-throughput detection of microeukaryotic parasites in insects using Nanopore sequencing.Microbial genomics · 2026Article
- Molecular identification of pelagic fish eggs with oil globule.Molecular biology reports · 2026Article
- Article
- Evidence of positive selection in the COI mitochondrial gene in the blue crab Callinectes sapidus (Decapoda: Portunidae).Scientific reports · 2025Article
- Building a DNA barcode library of commercially exploited fish genetic resources (FGR) of the Gomti River, Ganga basin, implications for conservation and management.Scientific reports · 2025Article
- Haplodiploidy accelerates mitogenome evolution in insects.Proceedings. Biological sciences · 2025Article
- Relative performance of three phylogenetic methods based on complete mitochondrial genomes of barnacle.Scientific reports · 2025Article
- Biomonitoring 2.0 Refined: observing local change through metaphylogeography using a community-based eDNA metabarcoding monitoring network.BMC biology · 2025Article
- Combination of Sample Preservation Approaches and DNA Extraction Methods for Long-Read Sequencing of Nudibranchs' Genomes.Ecology and evolution · 2025Article
- "Dark taxonomy": A new protocol for overcoming the taxonomic impediments for dark taxa and broadening the taxon base for biodiversity assessment.Cladistics : the international journal of the Willi Hennig Society · 2025Article
- DNA barcoding of passerine birds in Iran.ZooKeys · 2025Article
- Barcode 100K Specimens: In a Single Nanopore Run.Molecular ecology resources · 2025Article
- DNA barcoding and cryptic diversity in fishes from the Ili River Valley in China, Xinjiang.Ecology and evolution · 2024Article
- Evolution of a biological thermocouple by adaptation of cytochrome c oxidase in a subterrestrial metazoan, Halicephalobus mephisto.Communications biology · 2024Article
- Discrimination ofJournal of arthropod-borne diseases · 2024Article
9 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
DNA barcodes are widely used for identification and discovery of species. While such use draws on information at the DNA level, the current amassment of ca. 4.7 million COI barcodes also offers a unique resource for exploring functional constraints on DNA evolution. Here, we explore amino acid variation in a crosscut of the entire animal kingdom. Patterns of DNA variation were linked to functional constraints at the level of the amino acid sequence in functionally important parts of the enzyme. Six amino acid sites show variation with possible effects on enzyme function. Overall, patterns of amino acid variation suggest convergent or parallel evolution at the protein level connected to the transition into a parasitic life style. Denser sampling of two diverse insect taxa revealed that the beetles (Coleoptera) show more amino acid variation than the butterflies and moths (Lepidoptera), indicating fundamental difference in patterns of molecular evolution in COI. Several amino acid sites were found to be under notably strong purifying selection in Lepidoptera as compared to Coleoptera. Overall, these findings demonstrate the utility of the global DNA barcode library to extend far beyond identification and taxonomy, and will hopefully be followed by a multitude of work.
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