ArticleScientific reports2016
Identification of Comamonas testosteroni as an androgen degrader in sewage.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Potential relationship of the gut microbiome with testosterone level in men: a systematic review.PeerJ · 2025Pooled it
- Multi-Omics Reveals the Impact of Domestic Wastewater Input on the Dissolved Organic Carbon Pool and Microbial Community in the Qiantang River Estuary.Microorganisms · 2026Article
- Enrichment and characterization of steroid-degrading microbes for targeted removal of steroid hormone micropollutants in small-scale wastewater treatment solutions.Microbiology spectrum · 2025Article
- Identification of dehydrogenase, hydratase, and aldolase responsible for the propionyl residue removal in degradation of cholic acid C-17 side chain inMicrobiology spectrum · 2025Article
- Genomic and taxonomic characterization of the Comamonas sp. nov., a bacterium isolated from Brazilian Cerrado soil.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2025Article
- Environmental Impact of Xenobiotic Aromatic Compounds and Their Biodegradation Potential inInternational journal of molecular sciences · 2024Review
- Analyzing the Interaction betweenAnimals : an open access journal from MDPI · 2024Article
- Microbial degradation of contaminants of emerging concern: metabolic, genetic and omics insights for enhanced bioremediation.Frontiers in bioengineering and biotechnology · 2024Review
- Isolation and Characterization of Bacteria and Fungi Associated with Agarwood Fermentation.Current microbiology · 2022Article
- The Interplay between Androgen and Gut Microbiota: Is There a Microbiota-Gut-Testis Axis.Reproductive sciences (Thousand Oaks, Calif.) · 2022Review
- Polyhydroxyalkanoate Production byMicroorganisms · 2022Article
- Correlation Between Gut Microbiota and Testosterone in Male Patients With Type 2 Diabetes Mellitus.Frontiers in endocrinology · 2022Observational
- Culturomics revealed the bacterial constituents of the microbiota of a 10-year-old laboratory culture of planarian species S. mediterranea.Scientific reports · 2021Article
- Emergence of IMP-8-ProducingFrontiers in microbiology · 2021Article
- Influence of Diclofenac on Activated Sludge Bacterial Communities in Fed-Batch Reactors.Food technology and biotechnology · 2020Article
- Suitability of Immobilized Systems for Microbiological Degradation of Endocrine Disrupting Compounds.Molecules (Basel, Switzerland) · 2020Review
- Intimate communication between Comamonas aquatica and Fusarium solani in remediation of heavy metal-polluted environments.Archives of microbiology · 2020Article
- Microbial degradation of steroid sex hormones: implications for environmental and ecological studies.Microbial biotechnology · 2020Review
- Article
- Accelerated Biodegradation of the Agrochemical Ametoctradin by Soil-Derived Microbial Consortia.Frontiers in microbiology · 2020Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Numerous studies have reported the masculinization of freshwater wildlife exposed to androgens in polluted rivers. Microbial degradation is a crucial mechanism for eliminating steroid hormones from contaminated ecosystems. The aerobic degradation of testosterone was observed in various bacterial isolates. However, the ecophysiological relevance of androgen-degrading microorganisms in the environment is unclear. Here, we investigated the biochemical mechanisms and corresponding microorganisms of androgen degradation in aerobic sewage. Sewage samples collected from the Dihua Sewage Treatment Plant (Taipei, Taiwan) were aerobically incubated with testosterone (1 mM). Androgen metabolite analysis revealed that bacteria adopt the 9, 10-seco pathway to degrade testosterone. A metagenomic analysis indicated the apparent enrichment of Comamonas spp. (mainly C. testosteroni) and Pseudomonas spp. in sewage incubated with testosterone. We used the degenerate primers derived from the meta-cleavage dioxygenase gene (tesB) of various proteobacteria to track this essential catabolic gene in the sewage. The amplified sequences showed the highest similarity (87-96%) to tesB of C. testosteroni. Using quantitative PCR, we detected a remarkable increase of the 16S rRNA and catabolic genes of C. testosteroni in the testosterone-treated sewage. Together, our data suggest that C. testosteroni, the model microorganism for aerobic testosterone degradation, plays a role in androgen biodegradation in aerobic sewage.
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