ArticleScientific reports2016
Longer latency of sensory response to intravenous odor injection predicts olfactory neural disorder.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 24 citations in OpenAlex.
- Olfactory Bulb Volume and Function Recovery in Eosinophilic Chronic Rhinosinusitis.The Laryngoscope · 2026Observational
- Propriety of various examinations for subjective symptoms of olfactory disorders.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2024Article
- Repeated Bilateral Transcranial Direct Current Stimulation over Auditory Cortex for Tinnitus Treatment: A Double-Blinded Randomized Controlled Clinical Trial.Brain sciences · 2024Article
- Structures and functions of the normal and injured human olfactory epithelium.Frontiers in neural circuits · 2024Review
- Heterogeneous Damage to the Olfactory Epithelium in Patients with Post-Viral Olfactory Dysfunction.Journal of clinical medicine · 2023Article
- Correlation analysis of flow parameters in the olfactory cleft and olfactory function.Scientific reports · 2022Article
- Neural Circuitry for Stress Information of Environmental and Internal Odor Worlds.Frontiers in behavioral neuroscience · 2022Review
- Processing of Odor Information During the Respiratory Cycle in Mice.Frontiers in neural circuits · 2022Review
- Prognostic value of olfactory evoked potentials in patients with post-infectious olfactory dysfunction.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2021Article
- Thiazoline-related innate fear stimuli orchestrate hypothermia and anti-hypoxia via sensory TRPA1 activation.Nature communications · 2021Article
- Artificial hibernation/life-protective state induced by thiazoline-related innate fear odors.Communications biology · 2021Article
- Protective Effect of Insulin in Mouse Nasal Mucus Against Olfactory Epithelium Injury.Frontiers in neural circuits · 2021Article
- Linalool Odor-Induced Anxiolytic Effects in Mice.Frontiers in behavioral neuroscience · 2018Article
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Authors and funding
22 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A near loss of smell may result from conductive and/or neural olfactory disorders. However, an olfactory test to selectively detect neural disorders has not been established. We investigated whether onset latency of sensory response to intravenous odor injection can detect neural disorders in humans and mice. We showed that longer preoperative onset latency of odor recognition to intravenous odor in patients with chronic rhinosinusitis predicted worse recovery of olfactory symptoms following sinus surgery. The onset latency of the olfactory sensory neuron (OSN) response to intravenous odor using synaptopHluorin signals from OSN axon terminals was delayed in mice with reduced numbers of OSNs (neural disorder) but not with increased mucus or blocked orthonasal pathways (conductive disorders). Moreover, the increase in onset latency correlated with the decrease in mature OSN numbers. Longer onset latency to intravenous odor injection is a useful biomarker for presence and severity of olfactory disorders with neural etiology.
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