ArticleScientific reports2016
Bacterial intra-species gene loss occurs in a largely clocklike manner mostly within a pool of less conserved and constrained genes.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 38 citations in OpenAlex.
- Distribution and prevalence ofJournal of medical microbiology · 2025Article
- On the Origin and Evolution of Microbial Mercury Methylation.Genome biology and evolution · 2023Article
- Challenges and opportunities of strain diversity in gut microbiome research.Frontiers in microbiology · 2023Review
- Nutrition or nature: using elementary flux modes to disentangle the complex forces shaping prokaryote pan-genomes.BMC ecology and evolution · 2022Article
- Exploring the Role of the NO-Detoxifying Enzyme HmpA in the Evolution of Domesticated Alfalfa Rhizobia.Microbial ecology · 2022Article
- Reconstructing Gene Gains and Losses with BadiRate.Methods in molecular biology (Clifton, N.J.) · 2022Review
- Structures and function of the amino acid polymerase cyanophycin synthetase.Nature chemical biology · 2021Article
- Disentangling the impact of environmental and phylogenetic constraints on prokaryotic within-species diversity.The ISME journal · 2020Article
- Recombination and gene loss occur simultaneously during bacterial horizontal gene transfer.PloS one · 2020Article
- Genomic and Genotypic Characterization ofFrontiers in microbiology · 2018Article
- Genetic Competence Drives Genome Diversity in Bacillus subtilis.Genome biology and evolution · 2018Article
- Horizontally Acquired Genes Are Often Shared between Closely Related Bacterial Species.Frontiers in microbiology · 2017Article
- Similar levels of gene content variation observed for Pseudomonas syringae populations extracted from single and multiple host species.PloS one · 2017Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gene loss is a major contributor to the evolution of bacterial gene content. Gene loss may occur as a result of shifts in environment leading to changes in the intensity and/or directionality of selection applied for the maintenance of specific genes. Gene loss may also occur in a more neutral manner, when gene functions are lost that were not subject to strong selection to be maintained, irrespective of changes to environment. Here, we used a pangenome-based approach to investigate patterns of gene loss across 15 bacterial species. We demonstrate that gene loss tends to occur mostly within a pool of genes that are less constrained within species, even in those strains from which they are not lost, and less conserved across bacterial species. Our results indicate that shifts in selection, resulting from shifts in environment are not required to explain the majority of gene loss events occurring within a diverse collection of bacterial species. Caution should therefore be taken when attributing differences in gene content to differences in environment.
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