ArticleScientific reports2016
Early neuroimaging markers of FOXP2 intragenic deletion.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The neuroanatomy of developmental language disorder: a systematic review and meta-analysis.Nature human behaviour · 2024Pooled it
- Interventions for childhood apraxia of speech.The Cochrane database of systematic reviews · 2018Pooled it
- Comparative analysis of Foxp2 expression in the thalamus of mice, rats, and macaques: implications for the evolution of language circuits.Brain structure & function · 2026Article
- Childhood motor speech disorders: who to prioritise for genetic testing.European journal of human genetics : EJHG · 2026Article
- Interventions for childhood apraxia of speech.The Cochrane database of systematic reviews · 2026Article
- The effect of human-specific genetic variants on neuronal spinogenesis.Frontiers in genetics · 2026Review
- A Novel Candidate Neuromarker of Central Motor Dysfunction in Childhood Apraxia of Speech.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Speech and language classification in the human phenotype ontology.European journal of human genetics : EJHG · 2024Article
- Perisylvian and Hippocampal Anomalies in Individuals With PathogenicNeurology. Genetics · 2024Article
- Speech- and language-linked FOXP2 mutation targets protein motors in striatal neurons.Brain : a journal of neurology · 2023Article
- Young transposable elements rewired gene regulatory networks in human and chimpanzee hippocampal intermediate progenitors.Development (Cambridge, England) · 2022Article
- Atypical development of Broca's area in a large family with inherited stuttering.Brain : a journal of neurology · 2022Article
- Molecular networks of the FOXP2 transcription factor in the brain.EMBO reports · 2021Review
- FOXP2 expression and gray matter density in the male brains of patients with schizophrenia.Brain imaging and behavior · 2021Article
- Case Report: Expressive Speech Disorder in a Family as a Hallmark of 7q31 Deletion Involving theFrontiers in pediatrics · 2021Article
- Autism Spectrum Disorder and Childhood Apraxia of Speech: Early Language-Related Hallmarks across Structural MRI Study.Journal of personalized medicine · 2020Article
- FOXP transcription factors in vertebrate brain development, function, and disorders.Wiley interdisciplinary reviews. Developmental biology · 2020Review
- Functional characterization of two enhancers located downstream FOXP2.BMC medical genetics · 2019Article
- A Diagnostic Marker to Discriminate Childhood Apraxia of Speech From Speech Delay: I. Development and Description of the Pause Marker.Journal of speech, language, and hearing research : JSLHR · 2017Review
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
FOXP2 is the major gene associated with severe, persistent, developmental speech and language disorders. While studies in the original family in which a FOXP2 mutation was found showed volume reduction and reduced activation in core language and speech networks, there have been no imaging studies of different FOXP2 mutations. We conducted a multimodal MRI study in an eight-year-old boy (A-II) with a de novo FOXP2 intragenic deletion. A-II showed marked bilateral volume reductions in the hippocampus, thalamus, globus pallidus, and caudate nucleus compared with 26 control males (effect sizes from -1 to -3). He showed no detectable functional MRI activity when repeating nonsense words. The hippocampus is implicated for the first time in FOXP2 diseases. We conclude that FOXP2 anomaly is either directly or indirectly associated with atypical development of widespread subcortical networks early in life.
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