ArticlePlant biotechnology journal2017
Elevated acetyl-CoA by amino acid recycling fuels microalgal neutral lipid accumulation in exponential growth phase for biofuel production.
Article in Plant biotechnology journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Cadmium tolerance mediated by GhBCAT12 through branched-chain amino acid degradation via vacuolar sequestration in cotton.Stress biology · 2026Article
- Unveiling Metabolic Capability and Growth Adaptation ofInternational journal of molecular sciences · 2026Article
- Identifying genetic loci associated with drought tolerance in foxtail millet (Setaria italica).TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Article
- Regulation of carbon metabolic fluxes to enhance lipid and succinate production in oleaginous fungus Mortierella alpina.World journal of microbiology & biotechnology · 2024Article
- Potential of Mortierellaceae for polyunsaturated fatty acids production: mini review.Biotechnology letters · 2023Review
- Lipid Droplets from Plants and Microalgae: Characteristics, Extractions, and Applications.Biology · 2023Review
- Genome-Wide Characterization and Expression Analysis of Fatty acid Desaturase Gene Family in Poplar.International journal of molecular sciences · 2022Article
- Autophagy Improves ARA-Rich TAG Accumulation inMicrobiology spectrum · 2022Article
- RNA-seq analysis reveals genes related to photosynthetic carbon partitioning and lipid production inFrontiers in microbiology · 2022Article
- Nutrient Deficiency and an Algicidal Bacterium Improved the Lipid Profiles of a Novel Promising Oleaginous Dinoflagellate,Applied and environmental microbiology · 2021Article
- Role of the mitochondrial citrate-oxoglutarate carrier in lipid accumulation in the oleaginous fungus Mortierella alpina.Biotechnology letters · 2021Article
- Time-resolved multi-omics analysis reveals the role of nutrient stress-induced resource reallocation for TAG accumulation in oleaginous fungusBiotechnology for biofuels · 2020Article
- Subcellular Energetics and Carbon Storage inCells · 2019Review
- Branched-Chain Amino Acid Catabolism Impacts Triacylglycerol Homeostasis inPlant physiology · 2019Article
- Exploring the transcriptome of non-model oleaginous microalga Dunaliella tertiolecta through high-throughput sequencing and high performance computing.BMC bioinformatics · 2017Article
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7 authors.
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Abstract
Microalgal neutral lipids [mainly in the form of triacylglycerols (TAGs)], feasible substrates for biofuel, are typically accumulated during the stationary growth phase. To make microalgal biofuels economically competitive with fossil fuels, generating strains that trigger TAG accumulation from the exponential growth phase is a promising biological approach. The regulatory mechanisms to trigger TAG accumulation from the exponential growth phase (TAEP) are important to be uncovered for advancing economic feasibility. Through the inhibition of pyruvate dehydrogenase kinase by sodium dichloroacetate, acetyl-CoA level increased, resulting in TAEP in microalga Dunaliella tertiolecta. We further reported refilling of acetyl-CoA pool through branched-chain amino acid catabolism contributed to an overall sixfold TAEP with marginal compromise (4%) on growth in a TAG-rich D. tertiolecta mutant from targeted screening. Herein, a three-step α loop-integrated metabolic model is introduced to shed lights on the neutral lipid regulatory mechanism. This article provides novel approaches to compress lipid production phase and heightens lipid productivity and photosynthetic carbon capture via enhancing acetyl-CoA level, which would optimize renewable microalgal biofuel to fulfil the demanding fuel market.
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