Evidence map›Paper›PMID 27734309›Full record

ArticleMedical & biological engineering & computing2017

Cerebrovascular pattern improved by ozone autohemotherapy: an entropy-based study on multiple sclerosis patients.

Filippo Molinari, Daniele Rimini, William Liboni, U Rajendra Acharya, Marianno Franzini, Sergio Pandolfi, Giovanni Ricevuti, Francesco Vaiano, Luigi Valdenassi, Vincenzo Simonetti

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In one paragraph

Article in Medical & biological engineering & computing, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Filippo MolinariBiolab, Department of Electronics and Telecommunications, Politecnico di Torino, Corso Duca degli Abruzzi 24, 10129, Turin, Italy. filippo.molinari@polito.it.ORCID http://orcid.org/0000-0003-1150-2244
Daniele RiminiBiolab, Department of Electronics and Telecommunications, Politecnico di Torino, Corso Duca degli Abruzzi 24, 10129, Turin, Italy.
William Liboni"Un Passo Insieme" ONLUS Foundation, Valdellatorre, Turin, Italy.
U Rajendra AcharyaDepartment of Electronics and Computer Engineering, Ngee Ann Polytechnic, Clementi, 599489, Singapore.
Marianno FranziniScientific Society of Oxygen Ozone Therapy (SIOOT), Gorle, BG, Italy.
Sergio PandolfiScientific Society of Oxygen Ozone Therapy (SIOOT), Gorle, BG, Italy.
Giovanni RicevutiGeriatric and Emergency Medicine, Postgraduate School in Emergency Medicine, University of Pavia, Pavia, Italy.
Francesco VaianoScientific Society of Oxygen Ozone Therapy (SIOOT), Gorle, BG, Italy.
Luigi ValdenassiDepartment of Internal Medicine and Medical Therapy, University of Pavia, Pavia, Italy.
Vincenzo Simonetti"Kaos" ONLUS Foundation, Turin, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ozone major autohemotherapy is effective in reducing the symptoms of multiple sclerosis (MS) patients, but its effects on brain are still not clear. In this work, we have monitored the changes in the cerebrovascular pattern of MS patients and normal subjects during major ozone autohemotherapy by using near-infrared spectroscopy (NIRS) as functional and vascular technique. NIRS signals are analyzed using a combination of time, time-frequency analysis and nonlinear analysis of intrinsic mode function signals obtained from empirical mode decomposition technique. Our results show that there is an improvement in the cerebrovascular pattern of all subjects indicated by increasing the entropy of the NIRS signals. Hence, we can conclude that the ozone therapy increases the brain metabolism and helps to recover from the lower activity levels which is predominant in MS patients.

Indexed as

AdultBlood Flow VelocityBrainBrain MappingCerebrovascular CirculationEntropyFemaleHumansMaleMultiple SclerosisOxygen ConsumptionOzoneSpectroscopy, Near-InfraredThermodynamicsTreatment OutcomeOzoneCerebrovascular patternEmpirical mode decompositionEntropyMANOVAMultiple sclerosisNear-infrared spectroscopyOzone autohemotherapyTime–frequency

Identifiers

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.