ArticleDrugs & aging2016
Inappropriate Prescription and Renal Function Among Older Patients with Cognitive Impairment.
Article in Drugs & aging, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Drug-related problems and medication reviews among old people with dementia.BMC pharmacology & toxicology · 2017Trial
- The critical gap in kidney function monitoring for patients with dementia: clinical, ethical, and economic implications.Journal of nephrology · 2025Article
- Trends in renal function testing in patients with dementia: a repeated cross-sectional analysis in Australian general practice.Journal of nephrology · 2025Article
- Ten-Year Trend in the Potentially Inappropriate Prescribing of Renally-Dependent Medicines in Australian General Practice Patients with Dementia.Journal of clinical medicine · 2025Article
- Unintentional amitriptyline overdose leading to coma and cardiac conduction impairment in an older adult: A case report.SAGE open medical case reports · 2025Article
- Prevalence and Risk Factors of Inappropriate Drug Dosing among Older Adults with Dementia or Cognitive Impairment and Renal Impairment: A Systematic Review.Journal of clinical medicine · 2024Review
- Survival analysis of older adults with dementia: predicting factors after unplanned hospitalization in Maharaj Nakorn Chiang Mai Hospital.BMC geriatrics · 2024Article
- Characteristics of drug-related problems and pharmacist's interventions in hospitalized patients in Thailand: a prospective observational study.Scientific reports · 2022Observational
- Potentially inappropriate medications in relation to length of nursing home stay among older adults.BMC geriatrics · 2022Article
- Prioritising Risk Factors for Prescription Drug Overdose among Older Adults in South Korea: A Multi-Method Study.International journal of environmental research and public health · 2021Article
- Medical Students' and Internal Medicine Trainees' Knowledge of Drug Prescribing Recommendations in Older Patients with Impaired Kidney Function.Clinical interventions in aging · 2020Article
- Use of renal risk drugs in a nation-wide Polish older adult population: an analysis of PolSenior database.BMC geriatrics · 2019Article
- Differences in Kidney Function Estimates Based on Creatinine and/or Cystatin C in Non-Traumatic Amputation Patients and Their Impact on Drug Prescribing.Journal of clinical medicine · 2019Article
- Physician's Knowledge of Appropriate Prescribing for the Elderly-A Survey Among Family and Internal Medicine Physicians in Nigeria.Frontiers in pharmacology · 2019Article
- Clinically relevant drug-drug interactions among elderly people with dementia.European journal of clinical pharmacology · 2018Article
- Creatinine-Based Renal Function Estimates and Dosage of Postoperative Pain Management for Elderly Acute Hip Fracture Patients.Pharmaceuticals (Basel, Switzerland) · 2018Article
- Kidney function and use of nonsteroidal anti-inflammatory drugs among elderly people: a cross-sectional study on potential hazards for an at risk population.International journal of clinical pharmacy · 2018Article
- Effects of Pharmacists' Interventions on Inappropriate Drug Use and Drug-Related Readmissions in People with Dementia-A Secondary Analysis of a Randomized Controlled Trial.Pharmacy (Basel, Switzerland) · 2018Article
- Article
- Characterisation of Drug-Related Problems and Associated Factors at a Clinical Pharmacist Service-Naïve Hospital in Northern Sweden.Drugs - real world outcomes · 2017Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOlder people are more sensitive to drugs and adverse drug reactions than younger people because of age-related physiological changes such as impaired renal function. As people with dementia are particularly vulnerable to the effects of drugs, it is especially important to evaluate the dosages of renally cleared medications in this group.
objectiveThe aim of this study was to estimate the prevalence of impaired renal function and inappropriate prescriptions on the basis of renal function among older patients with dementia or cognitive impairment.
methodsThe medical records of 428 patients aged ≥65 years who were admitted to two hospitals in northern Sweden were reviewed and renally cleared medications were identified. The Cockcroft-Gault equation was used to evaluate renal function. Doses were evaluated according to the Geriatric Dosage Handbook.
resultsRenal function was impaired (estimated glomerular filtration rate <60 ml/min) in 65.4 % of the study population. Impaired renal function was associated with increasing age. Among 547 prescriptions identified as renally cleared medications, 9.1 % were inappropriate based on the patient's renal function; 13.5 % of the 326 patients prescribed renally cleared medications had inappropriate prescriptions. Inappropriate prescriptions were more common among patients living in nursing homes.
conclusionsImpaired renal function is common and inappropriate prescription is prevalent among old people with cognitive impairment in northern Sweden. Continuous consideration of renal function is important when prescribing medications to this group.
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