Evidence map›Paper›PMID 27734267›Full record

ArticleJournal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology2017

Anti-Inflammatory and Neuroprotective Effects of PGE

Suraj S Pradhan, Kirstie Salinas, Alexis C Garduno, Jenny U Johansson, Qian Wang, Amy Manning-Bog, Katrin I Andreasson

Abstract read
In one paragraph

Article in Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
1.1field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. The Role of PGE2 in Age-related Diseases.Current drug targets · 2025
    Review
  7. Review
  8. Article
  9. Review
  10. Review
  11. Article
  12. Lipid-Based Molecules on Signaling Pathways in Autism Spectrum Disorder.International journal of molecular sciences · 2022
    Review
  13. Review
  14. Review
  15. Article
  16. Article
  17. Oxidative stress-induced aberrant G9a activation disturbs RE-1-containing neuron-specific genes expression, leading to degeneration in human SH-SY5Y neuroblastoma cells.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2021
    Article
  18. Article
  19. Simple hypertrophic tonsils have more active innate immune and inflammatory responses than hypertrophic tonsils with recurrent inflammation in children.Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale · 2020
    Article
  20. The Aqueous Extract fromAntioxidants (Basel, Switzerland) · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 1 country.

Suraj S PradhanNeurosciences Graduate Program, Stanford University, Stanford, CA, USA. suraj16pradhan@gmail.com.
Kirstie SalinasNeurobiology Graduate Program, University of California Irvine, Irvine, CA, USA.
Alexis C GardunoProfusa, South San Francisco, CA, USA.
Jenny U JohanssonSRI International, Menlo Park, CA, USA.
Qian WangDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.
Amy Manning-BogAtreca, Redwood City, CA, USA.
Katrin I AndreassonDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.
Stanford University · USItasca Consultants (United States) · USProfusa (United States) · USSRI International · USUniversity of California, Irvine · US

Funding

Prostanoid signaling and inflammation in aging and Alzheimer's diseaseR01AG030209 · NIA · STANFORD UNIVERSITY · PI ANDREASSON, KATRIN I. · 2009 to 2013
$1.6M
Modulating Neuroinflammation via PGE2 signaling in models of ParkinsonismF31NS074712 · NINDS · STANFORD UNIVERSITY · PI PRADHAN, SURAJ SUNIL · 2012 to 2014
$79k
NIA NIH HHS R01 AG030209NINDS NIH HHS F31 NS074712
6 · The paper itself

Abstract

Inflammation is a ubiquitous factor accompanying normal aging and neurodegeneration, and recent studies indicate a major contribution of inducible cyclooxygenase (COX-2) and its downstream prostaglandin signaling pathways in modulating neuroinflammatory responses and neuronal function. We have previously shown that the prostaglandin PGE

Indexed as

AnimalsAnti-Inflammatory AgentsCells, CulturedDinoprostoneMaleMethyl EthersMiceMice, Inbred C57BLMice, KnockoutMice, TransgenicMicrogliaNeuroprotective AgentsParkinsonian DisordersReceptors, Prostaglandin E, EP4 SubtypeSignal TransductionAnti-Inflammatory AgentsDinoprostoneMethyl EthersNeuroprotective AgentsONO-AE1-329Ptger4 protein, mouseReceptors, Prostaglandin E, EP4 SubtypeAlpha synucleinEP4 receptorGPCRMicrogliaNeuroinflammationParkinson’s diseasePGE2

Identifiers

PMID27734267
PMCPMC5389937
OpenAlexW2530936502

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.