Evidence map›Paper›PMID 27734261›Full record

ReviewCurrent hematologic malignancy reports2016

Molecular Testing in Patients with Suspected Myelodysplastic Syndromes.

Tamara K Moyo, Michael R Savona

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current hematologic malignancy reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Trial
  2. Review
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Tamara K MoyoDepartment of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Michael R SavonaDepartment of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA. michael.savona@vanderbilt.edu.
Vanderbilt University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Myelodysplastic syndromes (MDS) comprise a heterogeneous group of clonal hematologic malignancies characterized by a hypercellular bone marrow and morphologic dysplasia in one or more lineage (i.e., myeloid, erythroid, or megakaryocytic), presenting clinically with leukopenia, anemia, and/or thrombocytopenia and with a propensity to transform to acute myelogenous leukemia. Newer technologies such as next-generation sequencing have allowed better understanding of the genetic landscape in MDS. Nearly 80 % of MDS patients have at least one mutation, and approximately 40 recurrent somatic mutations have been identified to occur in >1 % of cases. Many of these mutations are relevant for prognosis, help with selection of therapy, and/or have specific targeted treatment options. In this article, we will explore the impact of molecular testing on diagnosis, prognosis, and treatment decisions in patients with suspected MDS.

Indexed as

Antimetabolites, AntineoplasticDioxygenasesDNA-Binding ProteinsEnzyme InhibitorsGene FrequencyHigh-Throughput Nucleotide SequencingHumansMyelodysplastic SyndromesPhosphoproteinsPrognosisProto-Oncogene ProteinsRepressor ProteinsRNA Splicing FactorsSequence Analysis, DNAAntimetabolites, AntineoplasticASXL1 protein, humanDioxygenasesDNA-Binding ProteinsEnzyme InhibitorsPhosphoproteinsProto-Oncogene ProteinsRepressor ProteinsRNA Splicing FactorsSF3B1 protein, humanTET2 protein, humanClonal hematopoiesisMolecular analysisMyelodysplastic syndromes (MDS)

Identifiers

PMID27734261
OpenAlexW2530899026

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.