Evidence map›Paper›PMID 27734240›Full record

ArticleCancer causes & control : CCC2016

Sleep disruption, chronotype, shift work, and prostate cancer risk and mortality: a 30-year prospective cohort study of Finnish twins.

Barbra A Dickerman, Sarah C Markt, Markku Koskenvuo, Christer Hublin, Eero Pukkala, Lorelei A Mucci, Jaakko Kaprio

Abstract readTwin Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer causes & control : CCC, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 15 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed, 15 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

61 citing papers in PubMed, 15 syntheses or guidelines pooled it.

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  5. Association between night work and prostate cancer: a systematic review and meta-analysis.International archives of occupational and environmental health · 2024
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  9. Shift Work and Prostate Cancer: An Updated Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2020
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1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Barbra A DickermanDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Sarah C MarktDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Markku KoskenvuoDepartment of Public Health, University of Helsinki, P.O. Box 41, Mannerheimintie 172, 00014, Helsinki, Finland.
Christer HublinFinnish Institute of Occupational Health, Center of Expertise for the Development of Work and Organizations, Helsinki, Finland.
Eero PukkalaFinnish Cancer Registry, Institute for Statistical and Epidemiological Cancer Research, Unioninkatu 22, 00130, Helsinki, Finland.
Lorelei A MucciDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Jaakko KaprioDepartment of Public Health, University of Helsinki, P.O. Box 41, Mannerheimintie 172, 00014, Helsinki, Finland. jaakko.kaprio@helsinki.fi.

Funding

Statistical MethodsP01CA087969 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ELIASSEN, A. HEATHER · 2000 to 2019
$77.8M
Training Program in Cancer EpidemiologyT32CA009001 · NCI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI A. Heather Eliassen, Meir Stampfer · 1985 to 2026
$17.3M
NCI NIH HHS P01 CA087969NCI NIH HHS T32 CA009001
6 · The paper itself

Abstract

purposeSleep disruption and shift work have been associated with cancer risk, but epidemiologic evidence for prostate cancer remains limited. We aimed to prospectively investigate the association between midlife sleep- and circadian-related parameters and later prostate cancer risk and mortality in a population-based cohort of Finnish twins.

methodsData were drawn from the Older Finnish Twin Cohort and included 11,370 twins followed from 1981 to 2012. Over the study period, 602 incident cases of prostate cancer and 110 deaths from prostate cancer occurred. Cox regression was used to evaluate associations between midlife sleep duration, sleep quality, chronotype, and shift work with prostate cancer risk and prostate cancer-specific mortality. Within-pair co-twin analyses were employed to account for potential familial confounding.

resultsCompared to "definite morning" types, "somewhat evening" types had a significantly increased risk of prostate cancer (HR 1.3; 95 % CI 1.1, 1.6). Chronotype significantly modified the relationship between shift work and prostate cancer risk (p-interaction <0.001). We found no significant association between sleep duration, sleep quality, or shift work and prostate cancer risk in the overall analyses and no significant association between any sleep- or circadian-related parameter and risk in co-twin analyses. Neither sleep- nor circadian-related parameters were significantly associated with prostate cancer-specific mortality.

conclusionThe association between sleep disruption, chronotype, and shift work with prostate cancer risk and mortality has never before been studied in a prospective study of male twins. Our findings suggest that chronotype may be associated with prostate cancer risk and modify the association between shift work and prostate cancer risk. Future studies of circadian disruption and prostate cancer should account for this individual-level characteristic.

Indexed as

Work Schedule ToleranceAdultCircadian RhythmFemaleFinlandHumansIncidenceMaleMiddle AgedProspective StudiesProstatic NeoplasmsRiskSleepChronotypeProspective cohort studyProstate cancerShift workSleep durationSleep quality

Identifiers

PMID27734240
PMCPMC5278774

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.