Evidence map›Paper›PMID 27734228›Full record

ArticleJournal of autism and developmental disorders2017

Increased Risk for Substance Use-Related Problems in Autism Spectrum Disorders: A Population-Based Cohort Study.

Agnieszka Butwicka, Niklas Långström, Henrik Larsson, Sebastian Lundström, Eva Serlachius, Catarina Almqvist, Louise Frisén, Paul Lichtenstein

Open access · hybridAbstract read
In one paragraph

Article in Journal of autism and developmental disorders, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 147 citations in OpenAlex.

  1. Substance Use Disorder Outcomes and Treatment by Autism Status in Medicaid Enrollees With Substance Use Disorder.Autism research : official journal of the International Society for Autism Research · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Autistic traits and alcohol consumption through adolescence and young adulthood.medRxiv : the preprint server for health sciences · 2025
    Article
  7. Article
  8. Article
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  10. Article
  11. Review
  12. Alcohol and Disability Sports: Insights from Swiss Coaches.Substance abuse and rehabilitation · 2025
    Article
  13. Article
  14. Article
  15. Alcohol Use Patterns Among Underage Autistic and Non-Autistic Youth.Journal of autism and developmental disorders · 2024
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 2 countries.

Agnieszka ButwickaDepartment of Medical Epidemiology and Biostatistics, MEB, Karolinska Institutet, Box 281, 171 77, Stockholm, Sweden. agnieszka.butwicka@ki.se.ORCID 0000-0002-7247-2141
Niklas LångströmDepartment of Medical Epidemiology and Biostatistics, MEB, Karolinska Institutet, Box 281, 171 77, Stockholm, Sweden.
Henrik LarssonDepartment of Medical Epidemiology and Biostatistics, MEB, Karolinska Institutet, Box 281, 171 77, Stockholm, Sweden.
Sebastian LundströmDepartment of Neuroscience, Uppsala University, Uppsala, Sweden.
Eva SerlachiusDepartment of Clinical Neuroscience, Centre for Psychiatric Research, Karolinska Institutet, Stockholm, Sweden.
Catarina AlmqvistDepartment of Medical Epidemiology and Biostatistics, MEB, Karolinska Institutet, Box 281, 171 77, Stockholm, Sweden.
Louise FrisénDepartment of Clinical Neuroscience, Centre for Psychiatric Research, Karolinska Institutet, Stockholm, Sweden.
Paul LichtensteinDepartment of Medical Epidemiology and Biostatistics, MEB, Karolinska Institutet, Box 281, 171 77, Stockholm, Sweden.
Karolinska Institutet · SEStockholm County Council · SEUppsala University · SEMedical University of Warsaw · PLÖrebro University · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite limited and ambiguous empirical data, substance use-related problems have been assumed to be rare among patients with autism spectrum disorders (ASD). Using Swedish population-based registers we identified 26,986 individuals diagnosed with ASD during 1973-2009, and their 96,557 non-ASD relatives. ASD, without diagnosed comorbidity of attention deficit hyperactivity disorder (ADHD) or intellectual disability, was related to a doubled risk of substance use-related problems. The risk of substance use-related problems was the highest among individuals with ASD and ADHD. Further, risks of substance use-related problems were increased among full siblings of ASD probands, half-siblings and parents. We conclude that ASD is a risk factor for substance use-related problems. The elevated risks among relatives of probands with ASD suggest shared familial (genetic and/or shared environmental) liability.

Indexed as

Attention Deficit Disorder with HyperactivityAutism Spectrum DisorderChildCohort StudiesFemaleHumansMaleParentsRegistriesRisk FactorsSiblingsSubstance-Related DisordersSwedenAddictionADHDAutism spectrum disorderICDIntellectual disability

Identifiers

PMID27734228
PMCPMC5222913
OpenAlexW2531630191

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.