Trial reportAging clinical and experimental research2017
Association between GDF-15 levels and changes in vascular and physical function in older patients with hypertension.
Trial report in Aging clinical and experimental research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 45 citations in OpenAlex.
- The effect of exercise on GDF-15 levels in individuals with prediabetes: A randomized controlled trial.Journal of diabetes investigation · 2025Trial
- Growth differentiation factor 15 predicts physical function impairment in Spanish older adults: a real-world prospective study.GeroScience · 2026Article
- Growth Differentiation Factor 15 and Physical Function Impairment in the SardiNIA Study.Journal of clinical medicine · 2026Article
- GDF15 is associated with hepatocellular senescence and correlates with mortality in patients with alcohol-associated hepatitis.JHEP reports : innovation in hepatology · 2025Article
- The value of growth differentiation factor 15 as a biomarker for peripheral artery disease in diabetes patients.Diabetology & metabolic syndrome · 2025Article
- Impact of using supplemented thylakoids derived from spinach for 12 weeks of high-intensity functional training on adipo-myokines in obese males.Frontiers in nutrition · 2025Article
- Health implications of racial differences in serum growth differentiation factor levels among men with obesity.Physiological reports · 2024Article
- Article
- A Narrative Review on Adipose Tissue and Overtraining: Shedding Light on the Interplay among Adipokines, Exercise and Overtraining.International journal of molecular sciences · 2024Review
- Role and Mechanism of Growth Differentiation Factor 15 in Chronic Kidney Disease.Journal of inflammation research · 2024Review
- Effects of soy milk ingestion immediately after resistance training on muscular-related biomarkers in older men: a randomized controlled trial.Biology of sport · 2023Article
- The effect of metformin on influenza vaccine responses in nondiabetic older adults: a pilot trial.Immunity & ageing : I & A · 2023Article
- GDF-15 Is Associated with Poor Physical Function in Prefrail Older Adults with Diabetes.Journal of diabetes research · 2023Article
- The Effects of Exercise on Aging-Induced Exaggerated Cytokine Responses: An Interdisciplinary Discussion.Scientifica · 2022Review
- Changes in systemic GDF15 across the adult lifespan and their impact on maximal muscle power: the Copenhagen Sarcopenia Study.Journal of cachexia, sarcopenia and muscle · 2021Article
- Pathophysiology of Circulating Biomarkers and Relationship With Vascular Aging: A Review of the Literature From VascAgeNet Group on Circulating Biomarkers, European Cooperation in Science and Technology Action 18216.Frontiers in physiology · 2021Review
- Growth Differentiation Factor 15 in Severe Aortic Valve Stenosis: Relationship with Left Ventricular Remodeling and Frailty.Journal of clinical medicine · 2020Article
- Elevated serum growth differentiation factor 15 in multiple system atrophy patients: A case control study.World journal of clinical cases · 2020Article
- Serum GDF15, a Promising Biomarker in Obese Patients Undergoing Heart Surgery.Frontiers in cardiovascular medicine · 2020Article
- Relationship of growth differentiation factor-15 with aortic stiffness in essential hypertension.Future science OA · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundGrowth differentiation factor-15 (GDF-15) may be a biomarker of disease, protective response and/or prognosis, in older people with hypertension.
aimsTo correlate baseline GDF-15 levels with physical and vascular health data in this population.
methodsBaseline blood samples were analysed using a GDF-15 ELISA assay kit. Correlations with baseline and 12-month outcome data, including measures of physical and vascular function, were performed.
resultsA total of 147 individuals, mean age 76.8 ± 4.7 years, were included. 77 (52 %) were male. Baseline log
conclusionBaseline GDF-15 predicts declining physical, but not vascular, function in our population.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.