Evidence map›Paper›PMID 27734203›Full record

Trial reportSurgical endoscopy2017

Ten-year outcomes of a randomised trial of laparoscopic versus open surgery for colon cancer.

Charlotte L Deijen, Jeanine E Vasmel, Elly S M de Lange-de Klerk, Miguel A Cuesta, Peter-Paul L O Coene, Johan F Lange, W J H Jeroen Meijerink, Jack J Jakimowicz, Johannes Jeekel, Geert Kazemier and 5 more

Registry-linked trialOpen access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Surgical endoscopy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00387842 (A Randomized Clinical Trial Comparing Laparoscopic and Open Surgery for Colon Cancer), which is not on this map. Cited by 76 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
76citing papers in PubMed, 6 pooled it
5.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00387842 phase3unknown statusnot on this map

A Randomized Clinical Trial Comparing Laparoscopic and Open Surgery for Colon Cancer

TypeinterventionalSponsorErasmus Medical CenterRan1997 to 2008Enrolled1,200ConditionsColonic NeoplasmsArmsLaparoscopic surgery, Conventional surgery
3 · Its place in the literature

Who cites it

76 citing papers in PubMed, 6 syntheses or guidelines pooled it, 153 citations in OpenAlex.

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  18. Surgical treatment of colorectal cancer: A multidimensional review.World journal of gastrointestinal surgery · 2025
    Review
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16 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 7 institutions in 2 countries.

Charlotte L DeijenDepartment of Surgery, VU University Medical Centre, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands.
Jeanine E VasmelDepartment of Surgery, VU University Medical Centre, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands.
Elly S M de Lange-de KlerkDepartment of Surgery, VU University Medical Centre, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands.
Miguel A CuestaDepartment of Surgery, VU University Medical Centre, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands.
Peter-Paul L O CoeneDepartment of Surgery, Maasstad Hospital, Rotterdam, The Netherlands.
Johan F LangeDepartment of Surgery, Erasmus Medical Centre, Rotterdam, The Netherlands.
W J H Jeroen MeijerinkDepartment of Surgery, VU University Medical Centre, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands.
Jack J JakimowiczDepartment of Design Engineering, Delft University of Technology, Delft, The Netherlands.
Johannes JeekelDepartment of Surgery, Erasmus Medical Centre, Rotterdam, The Netherlands.
Geert KazemierDepartment of Surgery, VU University Medical Centre, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands.
Ignace M C JanssenDepartment of Surgery, Rijnstate Hospital, Arnhem, The Netherlands.
Lars PåhlmanDepartment of Surgery, Uppsala University Hospital, Uppsala, Sweden.
Eva HaglindDepartment of Surgery, Sahlgrenska University Hospital/Östra, Gothenburg, Sweden.
H Jaap BonjerDepartment of Surgery, VU University Medical Centre, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands. j.bonjer@vumc.nl.
COLOR (COlon cancer Laparoscopic or Open Resection) study group
Amsterdam UMC Location Vrije Universiteit Amsterdam · NLMaasstad Ziekenhuis · NLUppsala University Hospital · SEErasmus University Rotterdam · NLRijnstate Hospital · NLSahlgrenska University Hospital · SEVrije Universiteit Amsterdam · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLaparoscopic surgery for colon cancer is associated with improved recovery and similar cancer outcomes at 3 and 5 years in comparison with open surgery. However, long-term survival rates have rarely been reported. Here, we present survival and recurrence rates of the Dutch patients included in the COlon cancer Laparoscopic or Open Resection (COLOR) trial at 10-year follow-up.

methodsBetween March 1997 and March 2003, patients with non-metastatic colon cancer were recruited by 29 hospitals in eight countries and randomised to either laparoscopic or open surgery. Main inclusion criterion for the COLOR trial was solitary adenocarcinoma of the left or right colon. The primary outcome was disease-free survival at 3 years, and secondary outcomes included overall survival and recurrence. The 10-year follow-up data of all Dutch patients were collected. Analysis was by intention-to-treat. The trial was registered at ClinicalTrials.gov (NCT00387842).

resultsIn total, 1248 patients were randomised, of which 329 were Dutch. Fifty-eight Dutch patients were excluded and 15 were lost to follow-up, leaving 256 patients for 10-year analysis. Median follow-up was 112 months. Disease-free survival rates were 45.2 % in the laparoscopic group and 43.2 % in the open group (difference 2.0 %; 95 % confidence interval (CI) -10.3 to 14.3; p = 0.96). Overall survival rates were 48.4 and 46.7 %, respectively (difference 1.7 %; 95 % CI -10.6 to 14.0; p = 0.83). Stage-specific analysis revealed similar survival rates for both groups. Sixty-two patients were diagnosed with recurrent disease, accounting for 29.4 % in the laparoscopic group and 28.2 % in the open group (difference 1.2 %; 95 % CI -11.1 to 13.5; p = 0.73). Seven patients had port- or wound-site recurrences (laparoscopic n = 3 vs. open n = 4).

conclusionsLaparoscopic surgery for non-metastatic colon cancer is associated with similar rates of disease-free survival, overall survival and recurrences as open surgery at 10-year follow-up.

Indexed as

AdenocarcinomaAgedAged, 80 and overColonic NeoplasmsDisease-Free SurvivalEthnicityFemaleHumansLaparoscopyMaleMiddle AgedNeoplasm Recurrence, LocalNetherlandsSurvival RateColon cancerLaparoscopicRandomised clinical trialSurgeryTreatment

Identifiers

PMID27734203
PMCPMC5443846
OpenAlexW2531824796

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.