ArticleMetabolic brain disease2017
Cortical damage in Wernicke's encephalopathy with good prognosis: a report of two cases and literature review.
Article in Metabolic brain disease, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 22 citations in OpenAlex.
- Non-alcoholic Wernicke Encephalopathy With Atypical Cortical Involvement on MRI: A Case Report.Journal of community hospital internal medicine perspectives · 2026Article
- Cortical Involvement in Wernicke Encephalopathy.Internal medicine (Tokyo, Japan) · 2025Article
- Wernicke Encephalopathy: Typical and Atypical Findings in Alcoholics and Non-Alcoholics and Correlation with Clinical Symptoms.Clinical neuroradiology · 2024Observational
- Hand knob sign in Marchiafava-Bignami disease and Wernicke's encephalopathy.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Article
- An atypical presentation of Wernicke-Korsakoff encephalopathy mimicking a left hemispheric stroke: case report.Frontiers in psychiatry · 2024Article
- Letter to the Editor: Total parenteral nutrition-induced Wernicke's encephalopathy after oncologic gastrointestinal surgery.Open medicine (Warsaw, Poland) · 2024Article
- Article
- Gayet Wernicke's encephalopathy with cortical damage following a subtotal gastrectomy: An uncommon association.Radiology case reports · 2021Article
- Wernicke's encephalopathy-induced hearing loss complicating sleeve gastrectomy.BMJ case reports · 2020Article
- [Confusion, grand mal series and lactic acidosis in a 46-year-old woman].Der Nervenarzt · 2020Article
- A case of Wernicke's encephalopathy following complicated laparoscopic pylorus-preserving pancreaticoduodenectomy.Annals of hepato-biliary-pancreatic surgery · 2019Article
- Wernicke encephalopathy concurrent with polyradiculoneuropathy in a young man after bariatric surgery: A case report.Medicine · 2019Article
- Epileptic seizures in nonalcoholic Wernicke's encephalopathy: a case report and literature review.Metabolic brain disease · 2017Review
- Non-alcoholic Wernicke's encephalopathy with cortical involvement and polyneuropathy following gastrectomy.Metabolic brain disease · 2017Article
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Wernicke's encephalopathy (WE) is a thiamine deficiency-related condition, in which lesions are usually present in the periventricular and subcortical areas of the brain. However, lesions have also been found in atypical areas, such as the cerebral cortex. The present study summarizes the clinical outcomes and radiological features of WE with cortical impairment. We report two cases of cortical involvement in patients with WE, and review 22 similar cases from other reports. Among all 24 cases, 4 patients had a confirmed history of chronic daily alcohol abuse, and 19 of them had an identified causes of thiamine deficiency. 17 cases reported specific clinical information, among which 11 patients had symptoms of cortical impairment. 23 cases reported prognostic information at the end of treatment or at follow-up. The mortality rate was 26.1 % in our review. All patients had abnormal magnetic resonance imaging (MRI) signals or pathological findings in the bilateral cortex. Among patients with available MRI, 89.0 % had banding-like signs along the para-central sulcus. 13 cases underwent follow-up MRI examinations and 76.9 % displayed normal images. We suggest that WE with bilateral cortical involvement may have an acceptable prognosis, but that the mortality rate is higher than that among typical cases, especially if patients are not treated promptly and correctly. We identified the frontal and parietal lobes, especially around the central sulcus, to be the most susceptible areas, and suggest that the banding signs may be characteristic of WE. Persistent hyper-intensity on T2-weighted-fluid-attenuated inversion recovery, or gadolinium enhancement, may predict poor outcome.
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