ArticleMycopathologia2017
MALDI-TOF-Based Dermatophyte Identification.
Article in Mycopathologia, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed.
- Prospective multicenter evaluation of an easy-to-use DNA microarray for the detection of dermatophytes in clinical samples compared with conventional mycological methods.Microbiology spectrum · 2026Article
- Current Performance of MALDI-TOF Mass Spectrometry Databases for the Identification of Dermatophyte Species.Journal of fungi (Basel, Switzerland) · 2025Article
- Identification of Challenging Dermatophyte Species Using Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry.Journal of fungi (Basel, Switzerland) · 2025Article
- First Step on the Way to Identify Dermatophytes Using Odour Fingerprints.Mycopathologia · 2025Article
- Monocentric evaluation of the Novaplex dermatophyte multiplex qPCR assay in the diagnosis of dermatophytoses.Journal of clinical microbiology · 2024Article
- Resistance Profile, Terbinafine Resistance Screening and MALDI-TOF MS Identification of the Emerging Pathogen Trichophyton indotineae.Mycopathologia · 2024Article
- Performance of the VITEK® MS system for the identification of filamentous fungi in a microbiological laboratory in Chile.PloS one · 2024Article
- A comparative study for optimization of MALDI-TOF MS identification of filamentous fungi.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2023Article
- Dermatophytosis caused by trichophyton mentagrophytes complex in organic pigs.Acta veterinaria Scandinavica · 2023Article
- Breast abscess due to Nannizziopsis obscura in an immunocompromised renal transplant patient after travel to Nigeria: case report and review.BMC infectious diseases · 2023Article
- Evaluation of a Liquid Media MALDI-TOF MS Protocol for the Identification of Dermatophytes Isolated fromJournal of fungi (Basel, Switzerland) · 2022Article
- Mass spectrometry in research laboratories and clinical diagnostic: a new era in medical mycology.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2022Review
- Investigations upon the Improvement of Dermatophyte Identification Using an Online Mass Spectrometry Application.Journal of fungi (Basel, Switzerland) · 2022Article
- Loop-mediated isothermal amplification-microfluidic chip for the detection ofFrontiers in microbiology · 2022Article
- Matrix-Assisted Laser Desorption Ionization Time-of-Flight for Fungal Identification.Clinics in laboratory medicine · 2021Review
- Multilaboratory Evaluation of the MALDI-TOF Mass Spectrometry System, MicroIDSys Elite, for the Identification of Medically Important Filamentous Fungi.Mycopathologia · 2021Article
- Survey of dermatophytes in stray dogs and cats with and without skin lesions in Puerto Rico and confirmed with MALDI-TOF MS.PloS one · 2021Article
- Identification of Zoophilic Dermatophytes Using MALDI-TOF Mass Spectrometry.Frontiers in cellular and infection microbiology · 2021Article
- Recent trends in rapid diagnostic techniques for dermatophytosis.International journal of veterinary science and medicine · 2020Review
- Epidemiology and Diagnostic Perspectives of Dermatophytoses.Journal of fungi (Basel, Switzerland) · 2020Review
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
MALDI-TOF MS has become increasingly popular for microorganism identification in the routine laboratory. Compared with conventional morphology-based techniques, MALDI-TOF is relatively inexpensive (per-unit identification), involves a rapid result turnaround time and yields more accurate results without the need for highly qualified staff. However, this technology has been technically difficult to implement for filamentous fungi identification. Identification of dermatophytes, a type of filamentous fungi, remains particularly challenging, partly due to the lack of clear species definition for some taxa or within some species complexes. Review of the ten studies published between 2008 and 2015 shows that the accuracy of MALDI-TOF MS-based identification varied between 13.5 and 100 % for dermatophytes. This variability was partly due to inconsistencies concerning critical steps of the routine clinical laboratory process. Use of both a complete formic acid-acetonitrile protein extraction step and a manufacturer library supplemented with homemade reference spectra is essential for an accurate species identification. This technique is conversely unaffected by variations in other routine clinical laboratory conditions such as culture medium type, incubation time and type of mass spectrometry instrument. Provided that a reference spectra library is adequate for dermatophyte identification, MALDI-TOF MS identification is more economical and offers an accuracy comparable to that of DNA sequencing. The technique also represents an advantageous alternative to the protracted and labor-intensive dermatophyte identification via macroscopic and microscopic morphology in the routine clinical laboratory.
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