Evidence map›Paper›PMID 27734152›Full record

ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2017

Preliminary evaluation of a predictive blood assay to identify patients at high risk of chemotherapy-induced nausea.

Thomas Kutner, Emily Kunkel, Yue Wang, Kyle George, Erik L Zeger, Zonera A Ali, George C Prendergast, Paul B Gilman, U Margaretha Wallon

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Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Thomas KutnerLankenau Institute for Medical Research, Lankenau Medical Center, Wynnewood, PA, 19096, USA.
Emily KunkelLankenau Institute for Medical Research, Lankenau Medical Center, Wynnewood, PA, 19096, USA.
Yue WangHematology/Oncology Fellowship Program, Lankenau Medical Center, Wynnewood, PA, 19096, USA.
Kyle GeorgeLankenau Institute for Medical Research, Lankenau Medical Center, Wynnewood, PA, 19096, USA.
Erik L ZegerLankenau Institute for Medical Research, Lankenau Medical Center, Wynnewood, PA, 19096, USA.
Zonera A AliLankenau Institute for Medical Research, Lankenau Medical Center, Wynnewood, PA, 19096, USA.
George C PrendergastLankenau Institute for Medical Research, Lankenau Medical Center, Wynnewood, PA, 19096, USA.
Paul B GilmanLankenau Institute for Medical Research, Lankenau Medical Center, Wynnewood, PA, 19096, USA.
U Margaretha WallonLankenau Institute for Medical Research, Lankenau Medical Center, Wynnewood, PA, 19096, USA. wallon@limr.org.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe aim of this study was to test a new blood-based assay for its ability to predict delayed chemotherapy-induced nausea.

methodsBlood drawn from consented patients prior to receiving their first platinum-based therapy was tested for glutathione recycling capacity and normalized to total red cell numbers. This number was used to predict nausea and then compared to patient reported outcomes using the Rotterdam Symptom Check List and medical records.

resultsWe show that the pathways involved in the glutathione recycling are stable for at least 48 h and that the test was able to correctly classify the risk of nausea for 89.1 % of the patients. The overall incidence of nausea was 21.9 % while women had an incidence of 29.6 %.

conclusionsThis might be the first objective test to predict delayed nausea for cancer patients receiving highly emetogenic chemotherapy. We believe that this assay could better guide clinicians in their efforts to provide optimal patient-oriented care.

Indexed as

AdultAgedAged, 80 and overAntiemeticsFemaleHumansMaleMiddle AgedNauseaNeoplasmsProspective StudiesVomitingYoung AdultAntiemeticsBlood testCINVDelayed nauseaPredictive test

Identifiers

PMID27734152

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.