Trial reportIntensive care medicine2016
Complications of intravascular catheters in ICU: definitions, incidence and severity. A randomized controlled trial comparing usual transparent dressings versus new-generation dressings (the ADVANCED study).
Trial report in Intensive care medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04698824 (Hypnose en médecine Interne), which is not on this map. Cited by 28 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Hypnose en médecine Interne
Who cites it
28 citing papers in PubMed, 5 syntheses or guidelines pooled it, 105 citations in OpenAlex.
- Clinical Trials in Central Venous Access Devices: An Evidence and Gap Map.Journal of advanced nursing · 2026Pooled it
- Effectiveness and Safety of Different Dressing and Securement Methods for Peripheral Intravenous Catheters: A Systematic Review and Meta-Analysis.International wound journal · 2026Pooled it
- Dressings and securement devices to prevent complications for peripheral arterial catheters.The Cochrane database of systematic reviews · 2024Pooled it
- Development of central venous access device-associated skin impairment assessment instrument.Nursing open · 2022Pooled it
- Pooled it
- Securing Jugular Central Venous Catheters With Dressings Fixed to a Liquid Adhesive to Prevent Dressing Failure in Intensive Care Patients (the STICKY Trial): A Randomized Controlled Trial.Critical care medicine · 2025Trial
- Prevention of arterial catheter-related bloodstream infections: current evidence and future directions.Critical care (London, England) · 2026Review
- Influence of different short peripheral cannula materials on the incidence of phlebitis in intensive care units: A post-hoc analysis of the AMOR-VENUS study.Journal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures) · 2026Article
- Prediction of the ideal length of insertion to monitor left atrial pressures in pediatric open-heart surgery: a retrospective cohort study.BMC cardiovascular disorders · 2025Article
- Impact of Noradrenaline Administration Dosage on the Occurrence of Peripheral Intravenous Catheter-Related Venous Phlebitis in Critically Ill Patients Using a Time-Dependent Multilevel Cox Regression Model.Emergency medicine international · 2025Article
- Development of a Machine Learning-Based Model for Predicting the Incidence of Peripheral Intravenous Catheter-Associated Phlebitis.Journal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures) · 2024Article
- Incidence of asymptomatic catheter-related thrombosis in intensive care unit patients: a prospective cohort study.Annals of intensive care · 2023Article
- Impact of Radial Arterial Location on Catheter Lifetime in ICU Surgical Intensive Care.Critical care explorations · 2023Article
- Development and validation of a multivariable prediction model of central venous catheter-tip colonization in a cohort of five randomized trials.Critical care (London, England) · 2022Article
- Conditional catheter-related thrombosis free probability and risk-adapted choices of catheter for lung cancer.Thoracic cancer · 2022Article
- Risk factors for peripheral intravascular catheter-related phlebitis in critically ill patients: analysis of 3429 catheters from 23 Japanese intensive care units.Annals of intensive care · 2022Article
- Vascular access support teams: A multi-disciplinary response to optimise patient care during the COVID-19 pandemic.Journal of critical care · 2021Article
- Occurrence and incidence rate of peripheral intravascular catheter-related phlebitis and complications in critically ill patients: a prospective cohort study (AMOR-VENUS study).Journal of intensive care · 2021Article
- Expert consensus-based clinical practice guidelines management of intravascular catheters in the intensive care unit.Annals of intensive care · 2020Review
- Bloodstream infections in critically ill patients: an expert statement.Intensive care medicine · 2020Article
Corrections and comments
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Authors and funding
14 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo describe all post-insertion complications involving most used intravascular access, and to determine whether the use of a new-generation transparent dressing (3M™ IV Advanced) might reduce their number and impact on ICU patient outcomes.
methodsPatients older than 18, with an expected length of stay ≥48 h and requiring at least one central venous catheter (CVC), arterial catheter (AC), haemodialysis catheter (HDC), pulmonary arterial catheters (PAC) or peripheral venous catheter (PVC) were randomized into two groups: a new-generation transparent dressing, or the hospital's classical transparent dressing, and were followed daily for any infectious and non-infectious complications. Complications were graduated for severity by an independent international multicentre multidisciplinary panel of practitioners using a Delphi process.
resultsWe included 628 patients, 2214 catheters (873 PVCs, 630 CVCs, 512 ACs and 199 HDCs and PACs) and 4836 dressings. Overall incidence rate was of 60.9/1000 catheter-days. The most common complication was dysfunction (34.6/1000 catheter-days), mainly for PVCs (16/1000 catheter-days) and ACs (12.9/1000 catheter-days). Infectious complications incidence rate in CVCs and ACs was of 14.5/1000, mostly due to colonization (14.2/1000 catheter-days). Thrombosis incidence was of 3.8/1000 catheter-days with severe and very severe complications in 16 cases (1.8/1000 catheter-days) and one thrombosis-related death. 3M™ IV Advanced dressing did not decrease the rate of catheters with at least a minor complication [57.37/1000 vs. 57.52/1000 catheter-days, HR 1.03, CI (0.84-1.27), p = 0.81]. Incidence rates for each single complication remained equivalent: infectious [HR 0.93 (0.62-1.40), p = 0.72], deep thrombosis [HR 0.90 (0.39-2.06), p = 0.80], extravasation and phlebitis [HR 1.40 (0.69-2.82), p = 0.35], accidental removal [1.07 (0.56-2.04), p = 0.84] and dysfunction [HR 1.04 (0.80-1.35), p = 0.79].
conclusionThe ADVANCED study showed the overall risk of complications to intravascular catheters in ICU patients being dysfunction, infection and thrombosis. The 3M™ IV Advanced dressing did not decrease complication rates as compared to standard dressings.
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