Trial reportDiabetologia2017
Effects of insulin-induced hypoglycaemia on lipolysis rate, lipid oxidation and adipose tissue signalling in human volunteers: a randomised clinical study.
Trial report in Diabetologia, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01919788 (Intracellular Counter-regulatory Mechanisms Following Low Blood Glucose), which is not on this map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Intracellular Counter-regulatory Mechanisms Following Low Blood Glucose
Who cites it
12 citing papers in PubMed, 21 citations in OpenAlex.
- Decreased branched-chain amino acids and elevated fatty acids during antecedent hypoglycemia in type 1 diabetes.BMJ open diabetes research & care · 2023Trial
- Altered Caffeine Metabolism Is Associated With Recurrent Hypoglycemia in Type 2 Diabetes Mellitus: A UPLC-MS-Based Untargeted Metabolomics Study.Frontiers in endocrinology · 2022Trial
- Temporal patterns of lipolytic regulators in adipose tissue after acute growth hormone exposure in human subjects: A randomized controlled crossover trial.Molecular metabolism · 2019Trial
- The effects ofFrontiers in nutrition · 2023Article
- Personalized Biomechanical Analysis of the Mandible Teeth Behavior in the Treatment of Masticatory Muscles Parafunction.Journal of functional biomaterials · 2021Article
- How Perturbated Metabolites in Diabetes Mellitus Affect the Pathogenesis of Hypertension?Frontiers in physiology · 2021Review
- Alleviation of salt-induced exacerbation of cardiac, renal, and visceral fat pathology in rats with metabolic syndrome by surgical removal of subcutaneous fat.Nutrition & diabetes · 2020Article
- Article
- PET imaging during hypoglycaemia to study adipose tissue metabolism.European journal of clinical investigation · 2019Article
- Impact of Hypoglycemia on Brain Metabolism During Diabetes.Molecular neurobiology · 2018Review
- Youth With Type 1 Diabetes Have Adipose, Hepatic, and Peripheral Insulin Resistance.The Journal of clinical endocrinology and metabolism · 2018Article
- Androgen-Driven Dysregulation of Lipolysis in Cumulus Cells: Molecular Evidence and Metabolic Implications in Polycystic Ovary Syndrome.Reproductive medicine and biologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aims/hypothesisThe aims of this study were to determine the role of lipolysis in hypoglycaemia and define the underlying intracellular mechanisms.
methodsNine healthy volunteers were randomised to treatment order of three different treatments (crossover design). Treatments were: (1) saline control; (2) hyperinsulinaemic hypoglycaemia (HH; i.v. bolus of 0.1 U/kg insulin); and (3) hyperinsulinaemic euglycaemia (HE; i.v. bolus of 0.1 U/kg insulin and 20% glucose). Inclusion criteria were that volunteers were healthy, aged >18 years, had a BMI between 19 and 26 kg/m
resultsAdrenaline (epinephrine) and glucagon concentrations were higher during HH than during both HE and control treatments. NEFA levels and lipid oxidation rates (determined by indirect calorimetry) returned to control levels after 105 min. Palmitate flux was increased to control levels during HH (p = NS) and was more than twofold higher than during HE (overall mean difference between HH vs HE, 114 [95% CI 64, 165 μmol/min]; p < 0.001). In subcutaneous adipose tissue biopsies, we found elevated levels of hormone-sensitive lipase (HSL) and perilipin-1 phosphorylation 30 min after insulin injection during HH compared with both control and HE. There were no changes in the levels of adipose triglyceride lipase (ATGL), comparative gene identification-58 (CGI-58) or G CONCLUSIONS/
interpretationThese findings suggest that NEFAs become a major fuel source during insulin-induced hypoglycaemia and that lipolysis may be an important component of the counter-regulatory response. These effects appear to be mediated by rapid stimulation of protein kinase A (PKA) and HSL, compatible with activation of the β-adrenergic catecholamine signalling pathway.
trial registrationClinicalTrials.gov NCT01919788
funding: The study was funded by Aarhus University, the Novo Nordisk Foundation and the KETO Study Group/Danish Agency for Science Technology and Innovation (grant no. 0603-00479, to NM).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.